Q88YH5 (PGK_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	lp_0790

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus plantarum

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Phosphoglycerate kinase HAMAP-Rule MF_00145		PRO_0000145956
Regions
	Nucleotide binding	356 – 359	4	ATP By similarity
	Region	21 – 23	3	Substrate binding By similarity
	Region	59 – 62	4	Substrate binding By similarity
Sites
	Binding site	36	1	Substrate By similarity
	Binding site	119	1	Substrate By similarity
	Binding site	160	1	Substrate By similarity
	Binding site	211	1	ATP By similarity
	Binding site	329	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88YH5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1BD70A88477EF7A8	FASTA	400	42,797
	10 20 30 40 50 60 MAKLIVSDLD VKDKKVLIRV DFNVPIKDGK IGDDNRIVAA LPTIKYVIEH DGKAILFSHL 70 80 90 100 110 120 GRIKSEDDKK GLSLRPVAER LSNLLNKPVT FVPVTEGEQL ETAINNMNDG DVLVVENTRF 130 140 150 160 170 180 EDVVNGEQVK RESGNDPELG KYWASLGDVY VNDAFGTAHR SHASNVGIAS NMDQVAAGFL 190 200 210 220 230 240 MEKEIKFLGD AVDNPKHPFV AILGGAKVSD KIGVIDHLIS KADKIIIGGG MTYTFYAAKG 250 260 270 280 290 300 MGIGNSLVEK DKIELAKSII EKAGDKLVLP SDSIVAEKFD NDVPSKVVEG SIPDGYMALD 310 320 330 340 350 360 IGPKSIEEFE DVLRDAKTVV WNGPMGVFEM SNYAKGTLEI GKFLGTLSDA TTIVGGGDST 370 380 390 400 AAVKQLGVGD KLTHISTGGG ASLEYLEGKE LPGIAAISEK

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC78250.1.
RefSeq	YP_004888764.1. NC_004567.2.
3D structure databases
ProteinModelPortal	Q88YH5.
SMR	Q88YH5. Positions 2-400.
ModBase	Search...
Protein-protein interaction databases
STRING	220668.lp_0790.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CCC78250; CCC78250; lp_0790.
GeneID	1063805.
KEGG	lpl:lp_0790.
PATRIC	22247991. VBILacPla27411_0667.
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227107.
KO	K00927.
OMA	KFGLADK.
ProtClustDB	PRK00073.
Enzyme and pathway databases
UniPathway	UPA00109; UER00185.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
HAMAP	MF_00145. Phosphoglyc_kinase.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_LACPL

Accession

Primary (citable) accession number: Q88YH5
Secondary accession number(s): F9UM11

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program