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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171UniRule annotation1
Active sitei221Proton donorUniRule annotation1
Active sitei291UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciLPLA220668:G1GW0-708-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:lp_0814
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792211 – 302UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST302

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_0814

Structurei

3D structure databases

SMRiQ88YF4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 192FAD-binding PCMH-typeUniRule annotationAdd BLAST166

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D4A Bacteria
COG0812 LUCA
HOGENOMiHOG000284355
KOiK00075

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q88YF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDVLATFP AIEIKKNESL SHYTNTKTGG PADYVAFPKS ISETKALITF
60 70 80 90 100
ANEQNLPLTV IGNASNLIVK DGGIRGLTII LTRMKQIHAS GTKVVAEAGA
110 120 130 140 150
AIIATTKVAC GASLTGLEFA AGIPGSVGGA IFMNAGAYGG EMSEVVETVT
160 170 180 190 200
VLTPAGQLKT LDHDELDFGY RHSTIQDYDD IVVSVTFGLK PGNQTKIQAR
210 220 230 240 250
MDELNTLRAA KQPLEWPSCG SVFKRPTGYF TGKLIHDAGL QGHRIGGAEV
260 270 280 290 300
SKKHAGFIIN VDHATATDYM DMIHYVQKVV FERFGVHLQT EVRIIGEDVV

QG
Length:302
Mass (Da):32,333
Last modified:November 16, 2011 - v2
Checksum:i304D11368BB4FBC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA Translation: CCC78272.1
RefSeqiWP_003641067.1, NC_004567.2
YP_004888786.1, NC_004567.2

Genome annotation databases

EnsemblBacteriaiCCC78272; CCC78272; lp_0814
GeneIDi1063918
KEGGilpl:lp_0814
PATRICifig|220668.9.peg.689

Entry informationi

Entry nameiMURB_LACPL
AccessioniPrimary (citable) accession number: Q88YF4
Secondary accession number(s): F9UM33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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