Reviewed, UniProtKB/Swiss-Prot Q88YD9 (GLPK2_LACPL)

Names and origin

Protein names

Recommended name:
    Glycerol kinase 2
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase 2
    Glycerokinase 2
      Short name=GK 2

Gene names

Name:	glpK2
Ordered Locus Names:	lp_0834

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glycerol kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Glycerol kinase 2 HAMAP MF_00186		PRO_0000059461
Regions
	Nucleotide binding	411 – 415	5	ATP By similarity
Sites
	Binding site	13	1	Substrate By similarity
	Binding site	17	1	ATP By similarity
	Binding site	83	1	Substrate By similarity
	Binding site	135	1	Substrate By similarity
	Binding site	245	1	Substrate By similarity
	Binding site	267	1	ATP By similarity
	Binding site	310	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88YD9-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D76D1ED6C9FE922D	FASTA	508	55,952
	10 20 30 40 50 60 MSAKYIMAID EGTTSTRTII FNHAGQKVAD AQKEFPQYFP QPGWVEHDAT EIWNAVSSTI 70 80 90 100 110 120 ANVLIDANIK PNQIEAIGIT NQRETTVVWD KQTGLPIYNA IVWQSRQTAP LAEQLIADGM 130 140 150 160 170 180 GDLIHRHTGL VTDAYFSATK IRWILDHVDG AQKRAERGEL LFGTIDTWLV WKLTGGETHV 190 200 210 220 230 240 TDYTNASRTM LFNIHDLQWD QTILNLLNIP AAMLPEVRSN SEIYGTTKDY LLYGSQIPIS 250 260 270 280 290 300 GMAGDQQAAL FGQMAFEPGM VKNTYGTGAF TVMNLGEQPQ LSDHNLLTTI AYGLDGNINY 310 320 330 340 350 360 ALEGSIFVAG SALQWLRDGM QLIESAPESE SLAQQSHNHN EVYVVPAFTG LGAPYWDSET 370 380 390 400 410 420 RGAVFGLTRG TTRADFVKAT LQSLAYQSRD VIDTMKNDAN ITMPTLMVDG GAARNNWLMQ 430 440 450 460 470 480 FQADISNVKI IRAADLETTA LGAAFLAGLA VGYWQDLDEL KSIHQTGNVF QPRMAAPQRA 490 500 NLYQGWQAAV KAAQLFKHTP IDAQSSTN

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935254 Genomic DNA. Translation: CAD63416.1.
RefSeq	NP_784571.1.
3D structure databases
HSSP	HSSP built from PDB template 1GLC based on UniProtKB P08859.
SMR	Q88YD9. Positions 5-490.
ModBase	Search...
Genome annotation databases
GeneID	1064018.
GenomeReviews	Gene locus lp_0834 in contig AL935263_GR.
KEGG	lpl:lp_0834.
NMPDR	fig|220668.1.peg.705.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88YD9.
OMA	FGTINTW.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_0834-MON.
BRENDA	2.7.1.30. 593.
Family and domain databases
HAMAP	MF_00186. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK2_LACPL

Accession

Primary (citable) accession number: Q88YD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)