Q88Y75 (COAA_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	lp_0913

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Pantothenate kinase HAMAP MF_00215		PRO_0000194433
Regions
	Nucleotide binding	92 – 99	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q88Y75 [UniParc]. Last modified June 20, 2003. Version 1. Checksum: 55A1F1B6CB1A15BF	FASTA	309	36,558
	10 20 30 40 50 60 MEDQMNYYRF SREQWKQFYR NNQHQVPLTA ANLHEIEAFN DRISLDDVRD IYMPFAHLLQ 70 80 90 100 110 120 AKYEHYLSWR ETESVFLHRQ NRQSPFIIGV SGSVAVGKTT TARLLEILFK YLYPDRRTQL 130 140 150 160 170 180 ITTDGFLYPN AELKKMQLME RKGFPESYDM TRLIQFLNDV KSGKPLAKAP VYSHQTYDIV 190 200 210 220 230 240 PNRFDVITHP DILIIEGINV LQLPSNQAIY ISDFTDFSVY VDADADLIED WYLERFKALM 250 260 270 280 290 300 KTAFQDPTNY FYPWAIGDPK DAMAMAERVW EEVNLKNLND YILPTRNRAD LILHKVAHHV IDAVYFRKY

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC78353.1.
RefSeq	NP_784635.1. NC_004567.1.
3D structure databases
ProteinModelPortal	Q88Y75.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1062106.
GenomeReviews	Gene locus lp_0913 in contig AL935263_GR.
KEGG	lpl:lp_0913.
NMPDR	fig|220668.1.peg.769.
PATRIC	22248205. VBILacPla27411_0773.
Phylogenomic databases
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_0913-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_LACPL

Accession

Primary (citable) accession number: Q88Y75
Secondary accession number(s): F9UMB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	June 20, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program