Reviewed, UniProtKB/Swiss-Prot Q88Y40 (SYN1_LACPL)

Names and origin

Protein names

Recommended name:
    Asparaginyl-tRNA synthetase 1
    EC=6.1.1.22
Alternative name(s):
    Asparagine--tRNA ligase 1
      Short name=AsnRS 1

Gene names

Name:	asnS1
Ordered Locus Names:	lp_0956

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00534
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP asparagine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Asparaginyl-tRNA synthetase 1 HAMAP MF_00534		PRO_0000176418

Sequences

	Sequence		Length	Mass (Da)
	Q88Y40-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C9CB629A1E5EEEA4	FASTA	431	48,989
	10 20 30 40 50 60 METISIINAA DHVNEQVKIG VWLSNKRSSG KIAFLQLRDG TATFQGVALK NELGETAFAQ 70 80 90 100 110 120 LTDLAQETSL WVTGTIHADT RSPFGYELAI SQFEVVGTSH DYPITPKDHG IDFLLDHRHL 130 140 150 160 170 180 WLRSSRPNAI MRIRNEVIRA VYEFFNDRGF IKIDAPILTG SAPEGTTELF KTDYFGQDAY 190 200 210 220 230 240 LSQSGQLYGE AGAMAFGKIF TFGPTFRAEK SKTRRHLTEF WQLEPEMAWM HQDESLEVQE 250 260 270 280 290 300 QLVAYLGQAV IDHCPHELAV LDRDVATLQK YTKLPFPRVS YDDAITLLQA NGFDVDWGVD 310 320 330 340 350 360 FGSPEETFLA EHFDQPVFVL NYPKAIKAFY MQAHPTRDDV VIAADLLAPE GYGEIIGGSE 370 380 390 400 410 420 RSTDYDYLKE RLLASGQDLQ DYEWYLDLRK YGSVPHSGFG MGLERFLAWI TLQDHVRETI 430 PFPRMLHRIY P

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935254 Genomic DNA. Translation: CAD63517.1.
RefSeq	NP_784670.1.
3D structure databases
HSSP	HSSP built from PDB template 1B8A based on UniProtKB Q52428.
ModBase	Search...
Genome annotation databases
GeneID	1063894.
GenomeReviews	Gene locus lp_0956 in contig AL935263_GR.
KEGG	lpl:lp_0956.
NMPDR	fig|220668.1.peg.804.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88Y40.
OMA	LINHTER.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_0956-MON.
BRENDA	6.1.1.22. 593.
Family and domain databases
HAMAP	MF_00534. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp-tRNA-synth_IIb. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00457. asnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN1_LACPL

Accession

Primary (citable) accession number: Q88Y40

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)