Q88XU0 (AROB_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase
EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	lp_1086

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. HAMAP MF_00110 Divalent metal cations By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140748

Sequences

	Sequence		Length	Mass (Da)
	Q88XU0 [UniParc]. Last modified November 16, 2011. Version 2. Checksum: 622BC9C7023B6E0C	FASTA	359	38,105
	10 20 30 40 50 60 MTNIEVKTRV KQYQIKIMIN SLHHLGTLVT KVWCARQVAV VTDTNVGPYY AKLVTDELTA 70 80 90 100 110 120 AGFKVRVMTV PAGEESKSWS QVQSLIDQLS AAHFSRSDGV LALGGGVVGD LAGFVASIYM 130 140 150 160 170 180 RGIALIQVPT SLLAQVDSSV GGKTAIDLPT GKNLVGSFYQ PDLVVIDPAI LVTLPPRMLA 190 200 210 220 230 240 EGYGEIVKCA ALVGGDFWQS LHQITSVAAI LPAAPDLIAA SVAFKARVVM ADEHEQGQRQ 250 260 270 280 290 300 LLNFGHTIGH AVELLADGQL MHGEAVAIGL VQVCRLFAAH GLAPTSLTST LKARLMAVGL 310 320 330 340 350 PTELPPIAPQ AVAAVMQHDK KVHGTALTWV YLSAVGQPHL YPIAVTDLAT WMGDLWSVS

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC78491.1.
3D structure databases
ProteinModelPortal	Q88XU0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus lp_1086 in contig AL935263_GR.
KEGG	lpl:lp_1086.
NMPDR	fig|220668.1.peg.905.
PATRIC	22248513. VBILacPla27411_0920.
Phylogenomic databases
HOGENOM	HBG632303.
OMA	MADEHEQ.
ProtClustDB	PRK00002.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_1086-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
KO	K01735.
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. AroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_LACPL

Accession

Primary (citable) accession number: Q88XU0
Secondary accession number(s): F9UMQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	November 16, 2011
Last modified:	January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program