Q88XC3 (HEMH_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase
EC=4.99.1.1

Alternative name(s):
Heme synthase
Protoheme ferro-lyase

Gene names

Name:	hemH
Ordered Locus Names:	lp_1296

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Ferrochelatase HAMAP MF_00323		PRO_0000175153
Sites
	Metal binding	184	1	Iron By similarity
	Metal binding	266	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88XC3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: ADB238F15983DBD8	FASTA	324	36,370
	10 20 30 40 50 60 MHPGLLLVNL GSPASPRTKD VKAYLQEFLS DPSVIEMPAA LWQPLLRGII LPTRSWRSAT 70 80 90 100 110 120 FYQDSWLPQG SPLIVYSQAI CQQVQAALPD WNVRLAMTYG QPDIGATLKA MVADGCEKPI 130 140 150 160 170 180 ILPLFPQYTQ STHGGIHRQV EATGLPHTFI DSFYDQPTYI HLLATKVWQS YQAHHYDAVI 190 200 210 220 230 240 FSYHSIPTAM VRHGDPYQRE CEATTKAVLA ERPELPADKV ITAYQSKFGP MPWLKPYLKN 250 260 270 280 290 300 ELMQLVELGK RNVLVVTPSF VVDCLETLEE DYVQNYQTFR ASGGDRFDLV PPMNKDTGFS 310 320 QFLADLAIQK QEASNHAITS SSKS

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC78664.1.
RefSeq	NP_784944.1. NC_004567.1.
3D structure databases
ProteinModelPortal	Q88XC3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1062775.
GenomeReviews	Gene locus lp_1296 in contig AL935263_GR.
KEGG	lpl:lp_1296.
NMPDR	fig|220668.1.peg.1078.
PATRIC	22248899. VBILacPla27411_1096.
Phylogenomic databases
HOGENOM	HBG697135.
OMA	TIEEIGM.
ProtClustDB	CLSK821272.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_1296-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_LACPL

Accession

Primary (citable) accession number: Q88XC3
Secondary accession number(s): F9UN75

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program