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Q88XA9

- SYL_LACPL

UniProt

Q88XA9 - SYL_LACPL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (20 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei583 – 5831ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-1136-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:lp_1316
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 808808Leucine--tRNA ligasePRO_0000152030Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220668.lp_1316.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88XA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi580 – 5845"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q88XA9-1 [UniParc]FASTAAdd to Basket

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    MAYNHKVIER KWQHYWKENK TFKTLDTTDK KKYYALDMFP YPSGQGLHVG    50
    HPEGYTATDI MSRFKRMQGY NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT 100
    AKNIKNFKRQ IRSLGFSYDW DREVNTTDPS YYKWTQWIFE QLYKKGLAYE 150
    SETLVNWAPD MMGGTVVSNE EVVDGKTERG GYDVYRVPMK QWSLKITAYA 200
    DRLIDDLDDI DWPENIKEQQ RNWIGRSVGA SIRFKVAGQP DDTEIEVFST 250
    RPDTLFGASY MVLAPEHDLV EQLTTPEQAD AIKAYKAKIA SKSDLERTDL 300
    NKDKTGVFTG SYGINPVNGE KLPIWIADYV LASYGTGAIM AVPAHDDRDF 350
    EFAQKFDLPI KPVIAGDNDY DQQAYTGDGE HINSGFVDGL AKQPAIDKMI 400
    DWLGEHHAGE KKVNYRLRDW IFSRQRYWGE PIPVIHWEDG ETTLVPEDEL 450
    PLRLPATKNL EPSGTGESPL ANIDDWVNVV DENGRKGKRE TNTMPQWAGS 500
    SWYFLRYVDP HNREALADYD KLKYWSPVDL YVGGAEHAVL HLLYARFWHK 550
    FLYDLGVVPT KEPFQKLVNQ GMILGDNHEK MSKSRGNVVN PDDIVDQYGA 600
    DTLRLYEMFM GPLEASIPWS TDGLHGANKW IERVWRLMID ENNRVRDRIT 650
    TINDGKLTKI YNETVKKVTE DYEAMRFNIA ISQMMVFVNE AYKVDDLPII 700
    YIEGFVKLLS PIAPHLSEEL WSLLGHDDTI TYATWPTYDE SKLVEDTVQI 750
    VLQVNGKVRS HAEVAKDMGK DELEKLALAD EKIQEFTAGK TVRKVIAIPG 800
    KLVNVVAN 808
    Length:808
    Mass (Da):92,629
    Last modified:June 20, 2003 - v1
    Checksum:i68FE11F39F61821F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC78678.1.
    RefSeqiYP_004889192.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC78678; CCC78678; lp_1316.
    GeneIDi1062737.
    KEGGilpl:lp_1316.
    PATRICi22248927. VBILacPla27411_1110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC78678.1 .
    RefSeqi YP_004889192.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali Q88XA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_1316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC78678 ; CCC78678 ; lp_1316 .
    GeneIDi 1062737.
    KEGGi lpl:lp_1316.
    PATRICi 22248927. VBILacPla27411_1110.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.

    Enzyme and pathway databases

    BioCyci LPLA220668-WGS:GSPK-1136-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiSYL_LACPL
    AccessioniPrimary (citable) accession number: Q88XA9
    Secondary accession number(s): F9UN89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: June 20, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3