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Q88XA9

- SYL_LACPL

UniProt

Q88XA9 - SYL_LACPL

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-1136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:lp_1316
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Leucine--tRNA ligasePRO_0000152030Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_1316.

Structurei

3D structure databases

ProteinModelPortaliQ88XA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi580 – 5845"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88XA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYNHKVIER KWQHYWKENK TFKTLDTTDK KKYYALDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI MSRFKRMQGY NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT
110 120 130 140 150
AKNIKNFKRQ IRSLGFSYDW DREVNTTDPS YYKWTQWIFE QLYKKGLAYE
160 170 180 190 200
SETLVNWAPD MMGGTVVSNE EVVDGKTERG GYDVYRVPMK QWSLKITAYA
210 220 230 240 250
DRLIDDLDDI DWPENIKEQQ RNWIGRSVGA SIRFKVAGQP DDTEIEVFST
260 270 280 290 300
RPDTLFGASY MVLAPEHDLV EQLTTPEQAD AIKAYKAKIA SKSDLERTDL
310 320 330 340 350
NKDKTGVFTG SYGINPVNGE KLPIWIADYV LASYGTGAIM AVPAHDDRDF
360 370 380 390 400
EFAQKFDLPI KPVIAGDNDY DQQAYTGDGE HINSGFVDGL AKQPAIDKMI
410 420 430 440 450
DWLGEHHAGE KKVNYRLRDW IFSRQRYWGE PIPVIHWEDG ETTLVPEDEL
460 470 480 490 500
PLRLPATKNL EPSGTGESPL ANIDDWVNVV DENGRKGKRE TNTMPQWAGS
510 520 530 540 550
SWYFLRYVDP HNREALADYD KLKYWSPVDL YVGGAEHAVL HLLYARFWHK
560 570 580 590 600
FLYDLGVVPT KEPFQKLVNQ GMILGDNHEK MSKSRGNVVN PDDIVDQYGA
610 620 630 640 650
DTLRLYEMFM GPLEASIPWS TDGLHGANKW IERVWRLMID ENNRVRDRIT
660 670 680 690 700
TINDGKLTKI YNETVKKVTE DYEAMRFNIA ISQMMVFVNE AYKVDDLPII
710 720 730 740 750
YIEGFVKLLS PIAPHLSEEL WSLLGHDDTI TYATWPTYDE SKLVEDTVQI
760 770 780 790 800
VLQVNGKVRS HAEVAKDMGK DELEKLALAD EKIQEFTAGK TVRKVIAIPG

KLVNVVAN
Length:808
Mass (Da):92,629
Last modified:June 20, 2003 - v1
Checksum:i68FE11F39F61821F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC78678.1.
RefSeqiYP_004889192.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC78678; CCC78678; lp_1316.
GeneIDi1062737.
KEGGilpl:lp_1316.
PATRICi22248927. VBILacPla27411_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC78678.1 .
RefSeqi YP_004889192.1. NC_004567.2.

3D structure databases

ProteinModelPortali Q88XA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_1316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC78678 ; CCC78678 ; lp_1316 .
GeneIDi 1062737.
KEGGi lpl:lp_1316.
PATRICi 22248927. VBILacPla27411_1110.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.

Enzyme and pathway databases

BioCyci LPLA220668-WGS:GSPK-1136-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiSYL_LACPL
AccessioniPrimary (citable) accession number: Q88XA9
Secondary accession number(s): F9UN89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3