SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q88XA9

- SYL_LACPL

UniProt

Q88XA9 - SYL_LACPL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leucine--tRNA ligase
Gene
leuS, lp_1316
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-1136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:lp_1316
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Leucine--tRNA ligaseUniRule annotation
PRO_0000152030Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_1316.

Structurei

3D structure databases

ProteinModelPortaliQ88XA9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88XA9-1 [UniParc]FASTAAdd to Basket

« Hide

MAYNHKVIER KWQHYWKENK TFKTLDTTDK KKYYALDMFP YPSGQGLHVG    50
HPEGYTATDI MSRFKRMQGY NVLHPMGWDA FGLPAEQYAL KTGHNPKDFT 100
AKNIKNFKRQ IRSLGFSYDW DREVNTTDPS YYKWTQWIFE QLYKKGLAYE 150
SETLVNWAPD MMGGTVVSNE EVVDGKTERG GYDVYRVPMK QWSLKITAYA 200
DRLIDDLDDI DWPENIKEQQ RNWIGRSVGA SIRFKVAGQP DDTEIEVFST 250
RPDTLFGASY MVLAPEHDLV EQLTTPEQAD AIKAYKAKIA SKSDLERTDL 300
NKDKTGVFTG SYGINPVNGE KLPIWIADYV LASYGTGAIM AVPAHDDRDF 350
EFAQKFDLPI KPVIAGDNDY DQQAYTGDGE HINSGFVDGL AKQPAIDKMI 400
DWLGEHHAGE KKVNYRLRDW IFSRQRYWGE PIPVIHWEDG ETTLVPEDEL 450
PLRLPATKNL EPSGTGESPL ANIDDWVNVV DENGRKGKRE TNTMPQWAGS 500
SWYFLRYVDP HNREALADYD KLKYWSPVDL YVGGAEHAVL HLLYARFWHK 550
FLYDLGVVPT KEPFQKLVNQ GMILGDNHEK MSKSRGNVVN PDDIVDQYGA 600
DTLRLYEMFM GPLEASIPWS TDGLHGANKW IERVWRLMID ENNRVRDRIT 650
TINDGKLTKI YNETVKKVTE DYEAMRFNIA ISQMMVFVNE AYKVDDLPII 700
YIEGFVKLLS PIAPHLSEEL WSLLGHDDTI TYATWPTYDE SKLVEDTVQI 750
VLQVNGKVRS HAEVAKDMGK DELEKLALAD EKIQEFTAGK TVRKVIAIPG 800
KLVNVVAN 808
Length:808
Mass (Da):92,629
Last modified:June 20, 2003 - v1
Checksum:i68FE11F39F61821F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC78678.1.
RefSeqiYP_004889192.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC78678; CCC78678; lp_1316.
GeneIDi1062737.
KEGGilpl:lp_1316.
PATRICi22248927. VBILacPla27411_1110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC78678.1 .
RefSeqi YP_004889192.1. NC_004567.2.

3D structure databases

ProteinModelPortali Q88XA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_1316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC78678 ; CCC78678 ; lp_1316 .
GeneIDi 1062737.
KEGGi lpl:lp_1316.
PATRICi 22248927. VBILacPla27411_1110.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.

Enzyme and pathway databases

BioCyci LPLA220668-WGS:GSPK-1136-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiSYL_LACPL
AccessioniPrimary (citable) accession number: Q88XA9
Secondary accession number(s): F9UN89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi