Reviewed, UniProtKB/Swiss-Prot Q88X60 (CYSC_LACPL)

Names and origin

Protein names

Recommended name:
    Adenylyl-sulfate kinase
    EC=2.7.1.25
Alternative name(s):
    APS kinase
    Adenosine-5'-phosphosulfate kinase
    ATP adenosine-5'-phosphosulfate 3'-phosphotransferase

Gene names

Name:	cysC
Ordered Locus Names:	lp_1379

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylylsulfate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_0000105912
Regions
	Nucleotide binding	34 – 41	8	ATP By similarity
Sites
	Active site	108	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88X60-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F3E82E33AD96BF1D	FASTA	207	23,130
	10 20 30 40 50 60 MVKSDNITWH QSQVSKAERQ ALNHHKSVVL WFTGLSGSGK STIANAVEKA LFDQQVGSYV 70 80 90 100 110 120 LDGDNMRFGL NKNLGFSAED REENIRRIGE VAKLFVDAGV ITLTAFISPY RADRDKVRAN 130 140 150 160 170 180 LEVDEFIEVF VDTPLEVCEQ RDVKQLYAKA RRGEITGFTG IDAPYEAPID PEITIDTSKQ 190 200 PLTASVQQVL NYLAEHHYVS LVTANEN

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935256 Genomic DNA. Translation: CAD63855.1.
RefSeq	NP_785008.1.
3D structure databases
HSSP	HSSP built from PDB template 1M7G based on UniProtKB Q12657.
ModBase	Search...
Genome annotation databases
GeneID	1062562.
GenomeReviews	Gene locus lp_1379 in contig AL935263_GR.
KEGG	lpl:lp_1379.
NMPDR	fig|220668.1.peg.1142.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88X60.
OMA	Q88X60. IITITAF.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_1379-MON.
BRENDA	2.7.1.25. 593.
Family and domain databases
HAMAP	MF_00065. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
ProDom	PD002350. APS_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00455. apsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_LACPL

Accession

Primary (citable) accession number: Q88X60

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)