Reviewed, UniProtKB/Swiss-Prot Q88WR0 (URK_LACPL)

Names and origin

Protein names

Recommended name:
    Uridine kinase
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase
    Cytidine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	lp_1562

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine salvage Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Uridine kinase HAMAP MF_00551		PRO_0000164476
Regions
	Nucleotide binding	16 – 23	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q88WR0-1 [UniParc]. Last modified June 20, 2003. Version 1. Checksum: 7348D34CF899E17D	FASTA	209	24,054
	10 20 30 40 50 60 MTENKHRRPV VIGVTGGSGS GKTTVSNAIY NQLSGQSLLI LQQDSYYNDQ SEMTMAERHA 70 80 90 100 110 120 VNYDHPLAFD TDLMIKQIKQ LLAYQPIEKP VYDYEQYTRS DKTIHQEPRD VIIVEGVLIL 130 140 150 160 170 180 DDQRLRDLMD IKVFVDTDDD IRIIRRIQRD IKERGRTLDS VIGQYLATVK PMYHQFVEPT 190 200 KRYADLIVPE GGENEVAIDL LTTKVRSIL

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935256 Genomic DNA. Translation: CAD64008.1.
RefSeq	NP_785160.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1064138.
GenomeReviews	Gene locus lp_1562 in contig AL935263_GR.
KEGG	lpl:lp_1562.
NMPDR	fig|220668.1.peg.1294.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88WR0.
OMA	Q88WR0. NQFIEPT.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_1562-MON.
BRENDA	2.7.1.48. 593.
Family and domain databases
HAMAP	MF_00551. [Tree]
InterPro	IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view]
PANTHER	PTHR10285:SF6. Uridine_kin. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_LACPL

Accession

Primary (citable) accession number: Q88WR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	June 20, 2003
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)