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Protein

Guanylate kinase

Gene

gmk

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPLA220668:G1GW0-1387-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Synonyms:gmk1
Ordered Locus Names:lp_1612
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705521 – 206Guanylate kinaseAdd BLAST206

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_1612

Structurei

3D structure databases

ProteinModelPortaliQ88WL7
SMRiQ88WL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 184Guanylate kinase-likeUniRule annotationAdd BLAST180

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037639
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q88WL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQGMLIVL SGPSGVGKGT VRKEIFDSDD NDFQYSVSMT TRQMRPGEVD
60 70 80 90 100
GKDYYFVSKE EFEDEIKSGG MLEYAKYVDN YYGTPLKYIK QSLAAGKDVF
110 120 130 140 150
LEIEVNGAMQ VREKMPDGVF IFLTPPDLME LKHRIIGRGT DDMSVINKRM
160 170 180 190 200
AKAVDEIKMM RNYDYAVIND EVPLAAERIK AIIRSERFSV KRVMPEYEEM

LGDAES
Length:206
Mass (Da):23,461
Last modified:June 20, 2003 - v1
Checksum:i1F05F4B7E4088584
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA Translation: CCC78925.1
RefSeqiWP_003640361.1, NC_004567.2
YP_004889439.1, NC_004567.2

Genome annotation databases

EnsemblBacteriaiCCC78925; CCC78925; lp_1612
GeneIDi1063703
KEGGilpl:lp_1612
PATRICifig|220668.9.peg.1360

Similar proteinsi

Entry informationi

Entry nameiKGUA_LACPL
AccessioniPrimary (citable) accession number: Q88WL7
Secondary accession number(s): F9UNY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health