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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciLPLA220668:G137Z-1418-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:lp_1656
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543601 – 208N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST208

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_1656.

Structurei

3D structure databases

ProteinModelPortaliQ88WI1.
SMRiQ88WI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB. Bacteria.
COG0135. LUCA.
HOGENOMiHOG000161598.
KOiK01817.
OMAiFYAKSPR.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00697. PRAI. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88WI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQIKICGLM RPADVVMVNQ ALPDAIGMVF APGRRRRITM ATARQLSQQL
60 70 80 90 100
DPRIRRVGVF TTNQLSEILA LVQQHIIQVV QLHATVDDPR IASLMAAHVP
110 120 130 140 150
VIQAMTPANA TQCQADYLLL DNARPGSGQV LDWNQLQSQR PVRPFILAGG
160 170 180 190 200
LTPTNIVTAI NKVYPAMVDV ASGVETAGNK DREKINLMVQ RAHQTGVSTP

LLTEIRRN
Length:208
Mass (Da):22,828
Last modified:June 1, 2003 - v1
Checksum:i420252A909403ABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC78961.1.
RefSeqiWP_011101491.1. NC_004567.2.
YP_004889475.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC78961; CCC78961; lp_1656.
GeneIDi1061516.
KEGGilpl:lp_1656.
PATRICifig|220668.9.peg.1397.

Similar proteinsi

Entry informationi

Entry nameiTRPF_LACPL
AccessioniPrimary (citable) accession number: Q88WI1
Secondary accession number(s): F9UP22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families