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Q88W76

- FTHS_LACPL

UniProt

Q88W76 - FTHS_LACPL

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 688ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-1529-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:lp_1779
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_0000199354Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220668.lp_1779.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88W76.
    SMRiQ88W76. Positions 3-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q88W76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDIEIAQQV TPEPITAIAA KAGLTVDQID QYGSTKAKLK LPLPVKKTQR    50
    NLILVTSINP TPAGEGKSTV TIGLGDALTK IGKSTMIALR EPSLGPVMGM 100
    KGGATGGGYS QVIPMEDINL HFTGDMHALT AANNTLAALI DNHIQQGNQL 150
    GIDQRRIQWK RALDINDRAL RHTVIGLGGA TSGVPREDGF DITVASELMA 200
    ILCLSENIAD LKQRVNRIVI GYTHDRQPVT VADLNVGGAI TLLLKDALRP 250
    NLVQTLAHTP ALVHGGPFAN IAHGCNSVLA TQAGLNLADY TVTEAGFGAD 300
    LGGQKFMDIN VPAVGQAPNA VVIVATIRAL KLHGGVALQD LATENVAALK 350
    AGAANLGHHI HAMQRYGVPV VVAINEFTAD TDAEIHAVKD YCADLGVDAV 400
    LADVWGRGGD GATDLAAAVV DLCAQPSHFQ PLSPADADLK TKINDIVTKT 450
    YGGANVEYSA KAQRQLRTFA KQGWDHLPVC MAKTQYSLSD DPKRLGAPTG 500
    FTINVREFVP KLGAGFIVAL TGNVLTMPGL PKHPAALDMD ISDDGKISGL 550
    F 551
    Length:551
    Mass (Da):57,936
    Last modified:June 1, 2003 - v1
    Checksum:i6FA655CDF7526F7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79066.1.
    RefSeqiYP_004889580.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC79066; CCC79066; lp_1779.
    GeneIDi1064084.
    KEGGilpl:lp_1779.
    PATRICi22249717. VBILacPla27411_1500.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79066.1 .
    RefSeqi YP_004889580.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali Q88W76.
    SMRi Q88W76. Positions 3-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_1779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC79066 ; CCC79066 ; lp_1779 .
    GeneIDi 1064084.
    KEGGi lpl:lp_1779.
    PATRICi 22249717. VBILacPla27411_1500.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LPLA220668-WGS:GSPK-1529-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiFTHS_LACPL
    AccessioniPrimary (citable) accession number: Q88W76
    Secondary accession number(s): F9UPC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3