SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q88W76

- FTHS_LACPL

UniProt

Q88W76 - FTHS_LACPL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Formate--tetrahydrofolate ligase
Gene
fhs, lp_1779
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 688ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-1529-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:lp_1779
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199354Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_1779.

Structurei

3D structure databases

ProteinModelPortaliQ88W76.
SMRiQ88W76. Positions 3-549.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88W76-1 [UniParc]FASTAAdd to Basket

« Hide

MKDIEIAQQV TPEPITAIAA KAGLTVDQID QYGSTKAKLK LPLPVKKTQR    50
NLILVTSINP TPAGEGKSTV TIGLGDALTK IGKSTMIALR EPSLGPVMGM 100
KGGATGGGYS QVIPMEDINL HFTGDMHALT AANNTLAALI DNHIQQGNQL 150
GIDQRRIQWK RALDINDRAL RHTVIGLGGA TSGVPREDGF DITVASELMA 200
ILCLSENIAD LKQRVNRIVI GYTHDRQPVT VADLNVGGAI TLLLKDALRP 250
NLVQTLAHTP ALVHGGPFAN IAHGCNSVLA TQAGLNLADY TVTEAGFGAD 300
LGGQKFMDIN VPAVGQAPNA VVIVATIRAL KLHGGVALQD LATENVAALK 350
AGAANLGHHI HAMQRYGVPV VVAINEFTAD TDAEIHAVKD YCADLGVDAV 400
LADVWGRGGD GATDLAAAVV DLCAQPSHFQ PLSPADADLK TKINDIVTKT 450
YGGANVEYSA KAQRQLRTFA KQGWDHLPVC MAKTQYSLSD DPKRLGAPTG 500
FTINVREFVP KLGAGFIVAL TGNVLTMPGL PKHPAALDMD ISDDGKISGL 550
F 551
Length:551
Mass (Da):57,936
Last modified:June 1, 2003 - v1
Checksum:i6FA655CDF7526F7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79066.1.
RefSeqiYP_004889580.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79066; CCC79066; lp_1779.
GeneIDi1064084.
KEGGilpl:lp_1779.
PATRICi22249717. VBILacPla27411_1500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79066.1 .
RefSeqi YP_004889580.1. NC_004567.2.

3D structure databases

ProteinModelPortali Q88W76.
SMRi Q88W76. Positions 3-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_1779.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC79066 ; CCC79066 ; lp_1779 .
GeneIDi 1064084.
KEGGi lpl:lp_1779.
PATRICi 22249717. VBILacPla27411_1500.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LPLA220668-WGS:GSPK-1529-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiFTHS_LACPL
AccessioniPrimary (citable) accession number: Q88W76
Secondary accession number(s): F9UPC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi