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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway:itetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 688ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-1529-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:lp_1779
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_0000199354Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_1779.

Structurei

3D structure databases

ProteinModelPortaliQ88W76.
SMRiQ88W76. Positions 3-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88W76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIEIAQQV TPEPITAIAA KAGLTVDQID QYGSTKAKLK LPLPVKKTQR
60 70 80 90 100
NLILVTSINP TPAGEGKSTV TIGLGDALTK IGKSTMIALR EPSLGPVMGM
110 120 130 140 150
KGGATGGGYS QVIPMEDINL HFTGDMHALT AANNTLAALI DNHIQQGNQL
160 170 180 190 200
GIDQRRIQWK RALDINDRAL RHTVIGLGGA TSGVPREDGF DITVASELMA
210 220 230 240 250
ILCLSENIAD LKQRVNRIVI GYTHDRQPVT VADLNVGGAI TLLLKDALRP
260 270 280 290 300
NLVQTLAHTP ALVHGGPFAN IAHGCNSVLA TQAGLNLADY TVTEAGFGAD
310 320 330 340 350
LGGQKFMDIN VPAVGQAPNA VVIVATIRAL KLHGGVALQD LATENVAALK
360 370 380 390 400
AGAANLGHHI HAMQRYGVPV VVAINEFTAD TDAEIHAVKD YCADLGVDAV
410 420 430 440 450
LADVWGRGGD GATDLAAAVV DLCAQPSHFQ PLSPADADLK TKINDIVTKT
460 470 480 490 500
YGGANVEYSA KAQRQLRTFA KQGWDHLPVC MAKTQYSLSD DPKRLGAPTG
510 520 530 540 550
FTINVREFVP KLGAGFIVAL TGNVLTMPGL PKHPAALDMD ISDDGKISGL

F
Length:551
Mass (Da):57,936
Last modified:June 1, 2003 - v1
Checksum:i6FA655CDF7526F7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC79066.1.
RefSeqiWP_011101546.1. NC_004567.2.
YP_004889580.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79066; CCC79066; lp_1779.
GeneIDi1064084.
KEGGilpl:lp_1779.
PATRICi22249717. VBILacPla27411_1500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC79066.1.
RefSeqiWP_011101546.1. NC_004567.2.
YP_004889580.1. NC_004567.2.

3D structure databases

ProteinModelPortaliQ88W76.
SMRiQ88W76. Positions 3-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220668.lp_1779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCC79066; CCC79066; lp_1779.
GeneIDi1064084.
KEGGilpl:lp_1779.
PATRICi22249717. VBILacPla27411_1500.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciLPLA220668-WGS:GSPK-1529-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiFTHS_LACPL
AccessioniPrimary (citable) accession number: Q88W76
Secondary accession number(s): F9UPC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.