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Q88W76 (FTHS_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:lp_1779
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199354

Regions

Nucleotide binding61 – 688ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88W76 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6FA655CDF7526F7B

FASTA55157,936
        10         20         30         40         50         60 
MKDIEIAQQV TPEPITAIAA KAGLTVDQID QYGSTKAKLK LPLPVKKTQR NLILVTSINP 

        70         80         90        100        110        120 
TPAGEGKSTV TIGLGDALTK IGKSTMIALR EPSLGPVMGM KGGATGGGYS QVIPMEDINL 

       130        140        150        160        170        180 
HFTGDMHALT AANNTLAALI DNHIQQGNQL GIDQRRIQWK RALDINDRAL RHTVIGLGGA 

       190        200        210        220        230        240 
TSGVPREDGF DITVASELMA ILCLSENIAD LKQRVNRIVI GYTHDRQPVT VADLNVGGAI 

       250        260        270        280        290        300 
TLLLKDALRP NLVQTLAHTP ALVHGGPFAN IAHGCNSVLA TQAGLNLADY TVTEAGFGAD 

       310        320        330        340        350        360 
LGGQKFMDIN VPAVGQAPNA VVIVATIRAL KLHGGVALQD LATENVAALK AGAANLGHHI 

       370        380        390        400        410        420 
HAMQRYGVPV VVAINEFTAD TDAEIHAVKD YCADLGVDAV LADVWGRGGD GATDLAAAVV 

       430        440        450        460        470        480 
DLCAQPSHFQ PLSPADADLK TKINDIVTKT YGGANVEYSA KAQRQLRTFA KQGWDHLPVC 

       490        500        510        520        530        540 
MAKTQYSLSD DPKRLGAPTG FTINVREFVP KLGAGFIVAL TGNVLTMPGL PKHPAALDMD 

       550 
ISDDGKISGL F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC79066.1.
RefSeqYP_004889580.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ88W76.
SMRQ88W76. Positions 3-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_1779.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC79066; CCC79066; lp_1779.
GeneID1064084.
KEGGlpl:lp_1779.
PATRIC22249717. VBILacPla27411_1500.

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
ProtClustDBPRK13505.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LACPL
AccessionPrimary (citable) accession number: Q88W76
Secondary accession number(s): F9UPC7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways