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Protein

Peptide deformylase

Gene

def

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi113IronUniRule annotation1
Metal bindingi156IronUniRule annotation1
Active sitei157UniRule annotation1
Metal bindingi160IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciLPLA220668:G1GW0-1844-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Synonyms:def1
Ordered Locus Names:lp_2155
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827931 – 186Peptide deformylaseAdd BLAST186

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_2155

Structurei

3D structure databases

ProteinModelPortaliQ88VB2
SMRiQ88VB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243507
KOiK01462
OMAiMILMKDI

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q88VB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKMRDIIRE GNHTLRAEAK QVKFPLSEAD QKLANDMMEY LENSQDPELA
60 70 80 90 100
KKYGLRAGVG LAAPQVDVSE QMAAVLVPSE NEDDEPVFKD VIINPVIISH
110 120 130 140 150
SVQPGALTEG EGCLSVDRDI AGYVIRHDRI TLRYYNMAGE EKKIRLKNYP
160 170 180
AIVCQHEIDH LHGILFYDHI NGDNPFAADD DLVLIS
Length:186
Mass (Da):20,855
Last modified:June 1, 2003 - v1
Checksum:iE080FF56D7723576
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA Translation: CCC79383.1
RefSeqiWP_003645922.1, NC_004567.2
YP_004889897.1, NC_004567.2

Genome annotation databases

EnsemblBacteriaiCCC79383; CCC79383; lp_2155
GeneIDi1063706
KEGGilpl:lp_2155
PATRICifig|220668.9.peg.1824

Similar proteinsi

Entry informationi

Entry nameiDEF_LACPL
AccessioniPrimary (citable) accession number: Q88VB2
Secondary accession number(s): F9UQ94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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