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Q88VB2

- DEF_LACPL

UniProt

Q88VB2 - DEF_LACPL

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Protein

Peptide deformylase

Gene

def

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131IronUniRule annotation
Metal bindingi156 – 1561IronUniRule annotation
Active sitei157 – 1571UniRule annotation
Metal bindingi160 – 1601IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-1844-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Synonyms:def1
Ordered Locus Names:lp_2155
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Peptide deformylasePRO_0000082793Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_2155.

Structurei

3D structure databases

ProteinModelPortaliQ88VB2.
SMRiQ88VB2. Positions 1-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243507.
KOiK01462.
OMAiSQDPKIA.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88VB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKMRDIIRE GNHTLRAEAK QVKFPLSEAD QKLANDMMEY LENSQDPELA
60 70 80 90 100
KKYGLRAGVG LAAPQVDVSE QMAAVLVPSE NEDDEPVFKD VIINPVIISH
110 120 130 140 150
SVQPGALTEG EGCLSVDRDI AGYVIRHDRI TLRYYNMAGE EKKIRLKNYP
160 170 180
AIVCQHEIDH LHGILFYDHI NGDNPFAADD DLVLIS
Length:186
Mass (Da):20,855
Last modified:June 1, 2003 - v1
Checksum:iE080FF56D7723576
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79383.1.
RefSeqiYP_004889897.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79383; CCC79383; lp_2155.
GeneIDi1063706.
KEGGilpl:lp_2155.
PATRICi22250367. VBILacPla27411_1824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79383.1 .
RefSeqi YP_004889897.1. NC_004567.2.

3D structure databases

ProteinModelPortali Q88VB2.
SMRi Q88VB2. Positions 1-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_2155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC79383 ; CCC79383 ; lp_2155 .
GeneIDi 1063706.
KEGGi lpl:lp_2155.
PATRICi 22250367. VBILacPla27411_1824.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243507.
KOi K01462.
OMAi SQDPKIA.

Enzyme and pathway databases

BioCyci LPLA220668-WGS:GSPK-1844-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiDEF_LACPL
AccessioniPrimary (citable) accession number: Q88VB2
Secondary accession number(s): F9UQ94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3