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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciLPLA220668:G137Z-1869-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:lp_2199
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei53 – 73HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei110 – 130HelicalUniRule annotationAdd BLAST21
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei174 – 194HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei226 – 248HelicalUniRule annotationAdd BLAST23
Transmembranei252 – 274HelicalUniRule annotationAdd BLAST23
Transmembranei301 – 321HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088411 – 321Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST321

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_2199.

Structurei

3D structure databases

SMRiQ88V79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88V79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLVWGATL ISGFIIVFAL MPSLIRYFRA RKEGQMIREE GPKWHEKKSG
60 70 80 90 100
TPTMGGLLFI IAILVTTLWV GGWQHQLQPT TWILMFILVL YGALGFWDDS
110 120 130 140 150
IKLWRKQNEG LKAWQKLLGQ VIGAVILTLV YQHEHLPMAL RIPGLGVWSL
160 170 180 190 200
GIWYMLFAII WLVGFSNAVN LTDGLDGLVA GQATIAFGAY AVIAYAQNQY
210 220 230 240 250
NVMLFCLAVV GSLLGFFVYN HKPAKIFMGD MGSLALGGAL AAVSILLHHE
260 270 280 290 300
LSLLLIGIIF VIETASVILQ VASFKLTGKR IFLMSPIHHH FEMKGWSEWK
310 320
IDIVFWSIGL VAAVISVATI I
Length:321
Mass (Da):35,639
Last modified:June 1, 2003 - v1
Checksum:i3551D716DA9C5E0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC79417.1.
RefSeqiWP_003640859.1. NC_004567.2.
YP_004889931.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79417; CCC79417; lp_2199.
GeneIDi1063536.
KEGGilpl:lp_2199.
PATRICifig|220668.9.peg.1858.

Similar proteinsi

Entry informationi

Entry nameiMRAY_LACPL
AccessioniPrimary (citable) accession number: Q88V79
Secondary accession number(s): F9UQC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families