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Q88V61 (NADK_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:lp_2222
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267NAD kinase HAMAP-Rule MF_00361
PRO_0000120626

Regions

Nucleotide binding45 – 462NAD By similarity
Nucleotide binding122 – 1232NAD By similarity
Nucleotide binding161 – 1666NAD By similarity

Sites

Active site451Proton acceptor By similarity
Binding site1481NAD By similarity
Binding site1501NAD By similarity
Binding site1851NAD; via carbonyl oxygen By similarity
Binding site2231NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88V61 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 3D48E7004676EE7E

FASTA26729,825
        10         20         30         40         50         60 
MKVTIFANAS AKTKKVAGEL HTKLLAAGFE IDDEHPDIVL SVGGDGTLLA AFHHYSHMVD 

        70         80         90        100        110        120 
QVRFVGVHTG HLGFYTDWRD YEIDQLINGL LEDNGQSVTY PLLAVDITYA DTDATDHYLA 

       130        140        150        160        170        180 
LNESTLKKLG STMVADVYIQ DELFERFRGD GLCVSTPTGS TAYNKSVGGA VIHPRLDALQ 

       190        200        210        220        230        240 
MAEIASINNR VFRTLGSPVI VAPYETITIR PQQQSHFVFT ADQMDTQPRP IEQIRYSIAN 

       250        260 
RRIAFAQHRH NRFWQRVGTS FIGLDEQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC79435.1.
RefSeqYP_004889949.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ88V61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_2222.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC79435; CCC79435; lp_2222.
GeneID1062240.
KEGGlpl:lp_2222.
PATRIC22250473. VBILacPla27411_1877.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAWRADELE.

Enzyme and pathway databases

BioCycLPLA220668-WGS:GSPK-1896-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_LACPL
AccessionPrimary (citable) accession number: Q88V61
Secondary accession number(s): F9UQE6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families