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Q88UW5

- GSHAB_LACPL

UniProt

Q88UW5 - GSHAB_LACPL

Protein

Glutathione biosynthesis bifunctional protein GshAB

Gene

gshAB

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.By similarity

    Catalytic activityi

    ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
    ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-cysteine ligase activity Source: UniProtKB-EC
    3. glutathione synthase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Glutathione biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-2014-MONOMER.
    UniPathwayiUPA00142; UER00209.
    UPA00142; UER00210.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione biosynthesis bifunctional protein GshAB
    Alternative name(s):
    Gamma-GCS-GS
    Short name:
    GCS-GS
    Including the following 2 domains:
    Glutamate--cysteine ligase (EC:6.3.2.2)
    Alternative name(s):
    Gamma-ECS
    Short name:
    GCS
    Gamma-glutamylcysteine synthetase
    Glutathione synthetase (EC:6.3.2.3)
    Alternative name(s):
    GSH synthetase
    Short name:
    GS
    Short name:
    GSH-S
    Short name:
    GSHase
    Glutathione synthase
    Gene namesi
    Name:gshAB
    Synonyms:gshF
    Ordered Locus Names:lp_2336
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 751751Glutathione biosynthesis bifunctional protein GshABPRO_0000192552Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi220668.lp_2336.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88UW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 336336Glutamate--cysteine ligaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG1181.
    HOGENOMiHOG000112828.
    KOiK01919.
    OMAiHVEYVKN.

    Family and domain databases

    InterProiIPR007370. Glu_cys_ligase.
    [Graphical view]
    PfamiPF04262. Glu_cys_ligase. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q88UW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELDAVGKAI VQYHLVPLVH QANLGLEVTM HRVDAHGHLA TTAHPQAFGS    50
    AQQNHQLRPG FSASALKFTT PVRRDIPALM AYLKGLNTAA RRSLDADERL 100
    WPLSSTPVLP DDLTNVPLAD VDQVSYQRRR DLARKYELQR LMTTGSHVNM 150
    SLNEALFTRL YTETFHQQYH SYVDFRNAIY LKVAQGLVRM NWLIQYLFGA 200
    SPRLAVTDTT SRPQRSSVQH PDGRYSQVTG DYTSIDRYVA KLTAAVRQQQ 250
    LLSVNDFDGP VRLRSNGQLA MMARQGVYYL EYRGLDLDPT SPVGVDANAV 300
    AFVRLLASYF VMMPALPAKM VSQVNAQADQ LTRQVLGENP TTASAQAVPA 350
    VQVLDALADF VKTYGLPNED AVLLKQLKSW VTDPKKTLSA QIAMQADPLA 400
    WALERAARYQ ESSNERPFEL AGFTALDLSS QQLAQQALTR GVQVDVVDPH 450
    ANILRLTKLG RSQLVVNGSG TDLNPQALTT VLTHKAAAKQ ILAEHGVPVP 500
    ASQTYHTANQ LIADYDRYVQ AGGIVLKAAD ESHKVIVFRI MPERGLFEQV 550
    VRQLFEQTSA VMAEEVVVAS SYRFLVIDSR VQAIVERIPA NIVGDGRSTV 600
    KTLLDRKNGR ALRGTAFKWP QSALQLGTIE RYRLDSYHLT LDSVVSRGTQ 650
    ILLREDATFG NGADVLDATA DMHQSYVQAV EKLVADLHLA VAGVDVMIPN 700
    LYAELVPEHP EMAVYLGIHA APYLYPHLFP MFGTAQPVAG QLLDALFKNE 750
    D 751
    Length:751
    Mass (Da):83,018
    Last modified:June 1, 2003 - v1
    Checksum:i605A494E7A7DCBF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79530.1.
    RefSeqiYP_004890044.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC79530; CCC79530; lp_2336.
    GeneIDi1062357.
    KEGGilpl:lp_2336.
    PATRICi22250719. VBILacPla27411_1975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79530.1 .
    RefSeqi YP_004890044.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali Q88UW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_2336.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC79530 ; CCC79530 ; lp_2336 .
    GeneIDi 1062357.
    KEGGi lpl:lp_2336.
    PATRICi 22250719. VBILacPla27411_1975.

    Phylogenomic databases

    eggNOGi COG1181.
    HOGENOMi HOG000112828.
    KOi K01919.
    OMAi HVEYVKN.

    Enzyme and pathway databases

    UniPathwayi UPA00142 ; UER00209 .
    UPA00142 ; UER00210 .
    BioCyci LPLA220668-WGS:GSPK-2014-MONOMER.

    Family and domain databases

    InterProi IPR007370. Glu_cys_ligase.
    [Graphical view ]
    Pfami PF04262. Glu_cys_ligase. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiGSHAB_LACPL
    AccessioniPrimary (citable) accession number: Q88UW5
    Secondary accession number(s): F9UQP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3