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Q88UV8 (DDL_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:lp_2345
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177833

Regions

Domain142 – 348207ATP-grasp
Nucleotide binding172 – 22756ATP By similarity

Sites

Metal binding3021Magnesium or manganese 1 By similarity
Metal binding3151Magnesium or manganese 1 By similarity
Metal binding3151Magnesium or manganese 2 By similarity
Metal binding3171Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88UV8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 28F5EB160958095B

FASTA37041,347
        10         20         30         40         50         60 
METQKKIHVG MLFGGNSSEH DVSKRSAHNI YDAMDKNKYE IDLFLITKNG IVLSDAATRR 

        70         80         90        100        110        120 
VFDGEPEDQV VAEEMPKLDM SDPLAPIKNL TLAKDIDIFY PVVHGNLGED GTLQGLFKLL 

       130        140        150        160        170        180 
KKPYVGSGVL ASAASFDKDI TKQILTHHHI QNTKYVVVTP ENRDQMTYAY LQAHVGDHLF 

       190        200        210        220        230        240 
IKPANQGSSI GIHKAENEQE YLDGLADAFK YDYKILVEES IDNPREVECS ILGNENPKAS 

       250        260        270        280        290        300 
KLGAIDVPKT DTFYDYNNKF VDASGVTFEL PVELPADLTK RIQQMSLDAF KALGLKGMAR 

       310        320        330        340        350        360 
VDFLVSEDGE PYLGEINTLP GFTNISLYPK LWEVSGISYT ALIDQLIQLG FDEFKRQSDI 

       370 
HYDFVALDAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC79537.1.
RefSeqYP_004890051.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ88UV8.
SMRQ88UV8. Positions 6-358.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_2345.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC79537; CCC79537; lp_2345.
GeneID1062361.
KEGGlpl:lp_2345.
PATRIC22250733. VBILacPla27411_1982.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
ProtClustDBPRK01966.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_LACPL
AccessionPrimary (citable) accession number: Q88UV8
Secondary accession number(s): F9UQP8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways