Q88UU5 (MURA1_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
EC=2.5.1.7

Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name=EPT 1

Gene names

Name:	murA1
Ordered Locus Names:	lp_2361

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus plantarum

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP-Rule MF_00111		PRO_0000178881
Sites
	Active site	119	1	Proton donor By similarity
Amino acid modifications
	Modified residue	119	1	2-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88UU5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E48B4C5686B3A8AA	FASTA	438	47,147
	10 20 30 40 50 60 MEEIVVHGGQ RLTGNVHIEG AKNAVLPILA ASLLASSGQT HLSNVPVLSD VFTMNNVLKF 70 80 90 100 110 120 LNTKIDFDEI NKTIDIDASR QLSSEAPFQY VSKMRASIVV MGPLLARLGH AKVAMPGGCA 130 140 150 160 170 180 IGSRPIDLHL KGLNALGAEI ERHDGYVEAT ANQLHGAAIY LDFPSVGATQ NIMMAATLAD 190 200 210 220 230 240 GITTMENVAR EPEIVDLANY LNQMGAKVTG AGTETIRIEG VKAMHGCDHS IVQDRIEAGT 250 260 270 280 290 300 FMVAAAVTQG NVLVEDAIAE HNKPLISKMR EMGVTVTEEP AGIRVIGPEI LKPTSVKTMP 310 320 330 340 350 360 HPGFPTDMQP QMTILQLCAQ GTSLLTETVF ENRFMHLDEL RRMNADFKVE GRSVIMYGPT 370 380 390 400 410 420 DFNGAQVTAT DLRAAAALVI AGLVSRGYTE VTNLKYLDRG YFNFHGKLAK LGAEIKRVDV 430 PDGTVYALNP DFANEAAE

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC79550.1.
RefSeq	YP_004890064.1. NC_004567.2.
3D structure databases
ProteinModelPortal	Q88UU5.
ModBase	Search...
Protein-protein interaction databases
STRING	220668.lp_2361.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CCC79550; CCC79550; lp_2361.
GeneID	1062393.
KEGG	lpl:lp_2361.
PATRIC	22250759. VBILacPla27411_1995.
Phylogenomic databases
eggNOG	COG0766.
HOGENOM	HOG000075602.
KO	K00790.
OMA	LSDVFMM.
ProtClustDB	PRK09369.
Enzyme and pathway databases
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.65.10.10. 2 hits.
HAMAP	MF_00111. MurA.
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
PANTHER	PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_LACPL

Accession

Primary (citable) accession number: Q88UU5
Secondary accession number(s): F9UQR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program