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Q88UU5

- MURA1_LACPL

UniProt

Q88UU5 - MURA1_LACPL

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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene
murA1, lp_2361
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Proton donor By similarity

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
  5. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-2034-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (EC:2.5.1.7)
Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name:
EPT 1
Gene namesi
Name:murA1
Ordered Locus Names:lp_2361
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotationPRO_0000178881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei119 – 11912-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_2361.

Structurei

3D structure databases

ProteinModelPortaliQ88UU5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiVTDIYHI.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88UU5-1 [UniParc]FASTAAdd to Basket

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MEEIVVHGGQ RLTGNVHIEG AKNAVLPILA ASLLASSGQT HLSNVPVLSD    50
VFTMNNVLKF LNTKIDFDEI NKTIDIDASR QLSSEAPFQY VSKMRASIVV 100
MGPLLARLGH AKVAMPGGCA IGSRPIDLHL KGLNALGAEI ERHDGYVEAT 150
ANQLHGAAIY LDFPSVGATQ NIMMAATLAD GITTMENVAR EPEIVDLANY 200
LNQMGAKVTG AGTETIRIEG VKAMHGCDHS IVQDRIEAGT FMVAAAVTQG 250
NVLVEDAIAE HNKPLISKMR EMGVTVTEEP AGIRVIGPEI LKPTSVKTMP 300
HPGFPTDMQP QMTILQLCAQ GTSLLTETVF ENRFMHLDEL RRMNADFKVE 350
GRSVIMYGPT DFNGAQVTAT DLRAAAALVI AGLVSRGYTE VTNLKYLDRG 400
YFNFHGKLAK LGAEIKRVDV PDGTVYALNP DFANEAAE 438
Length:438
Mass (Da):47,147
Last modified:June 1, 2003 - v1
Checksum:iE48B4C5686B3A8AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79550.1.
RefSeqiYP_004890064.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79550; CCC79550; lp_2361.
GeneIDi1062393.
KEGGilpl:lp_2361.
PATRICi22250759. VBILacPla27411_1995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79550.1 .
RefSeqi YP_004890064.1. NC_004567.2.

3D structure databases

ProteinModelPortali Q88UU5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_2361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC79550 ; CCC79550 ; lp_2361 .
GeneIDi 1062393.
KEGGi lpl:lp_2361.
PATRICi 22250759. VBILacPla27411_1995.

Phylogenomic databases

eggNOGi COG0766.
HOGENOMi HOG000075602.
KOi K00790.
OMAi VTDIYHI.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci LPLA220668-WGS:GSPK-2034-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00111. MurA.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view ]
PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01072. murA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiMURA1_LACPL
AccessioniPrimary (citable) accession number: Q88UU5
Secondary accession number(s): F9UQR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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