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Q88UU5 (MURA1_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name=EPT 1
Gene names
Name:murA1
Ordered Locus Names:lp_2361
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP-Rule MF_00111
PRO_0000178881

Sites

Active site1191Proton donor By similarity

Amino acid modifications

Modified residue11912-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88UU5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E48B4C5686B3A8AA

FASTA43847,147
        10         20         30         40         50         60 
MEEIVVHGGQ RLTGNVHIEG AKNAVLPILA ASLLASSGQT HLSNVPVLSD VFTMNNVLKF 

        70         80         90        100        110        120 
LNTKIDFDEI NKTIDIDASR QLSSEAPFQY VSKMRASIVV MGPLLARLGH AKVAMPGGCA 

       130        140        150        160        170        180 
IGSRPIDLHL KGLNALGAEI ERHDGYVEAT ANQLHGAAIY LDFPSVGATQ NIMMAATLAD 

       190        200        210        220        230        240 
GITTMENVAR EPEIVDLANY LNQMGAKVTG AGTETIRIEG VKAMHGCDHS IVQDRIEAGT 

       250        260        270        280        290        300 
FMVAAAVTQG NVLVEDAIAE HNKPLISKMR EMGVTVTEEP AGIRVIGPEI LKPTSVKTMP 

       310        320        330        340        350        360 
HPGFPTDMQP QMTILQLCAQ GTSLLTETVF ENRFMHLDEL RRMNADFKVE GRSVIMYGPT 

       370        380        390        400        410        420 
DFNGAQVTAT DLRAAAALVI AGLVSRGYTE VTNLKYLDRG YFNFHGKLAK LGAEIKRVDV 

       430 
PDGTVYALNP DFANEAAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC79550.1.
RefSeqYP_004890064.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ88UU5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_2361.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC79550; CCC79550; lp_2361.
GeneID1062393.
KEGGlpl:lp_2361.
PATRIC22250759. VBILacPla27411_1995.

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMAVTDIYHI.

Enzyme and pathway databases

BioCycLPLA220668-WGS:GSPK-2034-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA1_LACPL
AccessionPrimary (citable) accession number: Q88UU5
Secondary accession number(s): F9UQR1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways