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Q88UU5

- MURA1_LACPL

UniProt

Q88UU5 - MURA1_LACPL

Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene

murA1

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

    Catalytic activityi

    Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei119 – 1191Proton donorUniRule annotation

    GO - Molecular functioni

    1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW
    5. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-2034-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotation (EC:2.5.1.7UniRule annotation)
    Alternative name(s):
    Enoylpyruvate transferase 1UniRule annotation
    UDP-N-acetylglucosamine enolpyruvyl transferase 1UniRule annotation
    Short name:
    EPT 1UniRule annotation
    Gene namesi
    Name:murA1UniRule annotation
    Ordered Locus Names:lp_2361
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1PRO_0000178881Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei119 – 11912-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi220668.lp_2361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88UU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0766.
    HOGENOMiHOG000075602.
    KOiK00790.
    OMAiVTDIYHI.

    Family and domain databases

    Gene3Di3.65.10.10. 2 hits.
    HAMAPiMF_00111. MurA.
    InterProiIPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view]
    PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
    PfamiPF00275. EPSP_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR01072. murA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88UU5-1 [UniParc]FASTAAdd to Basket

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    MEEIVVHGGQ RLTGNVHIEG AKNAVLPILA ASLLASSGQT HLSNVPVLSD    50
    VFTMNNVLKF LNTKIDFDEI NKTIDIDASR QLSSEAPFQY VSKMRASIVV 100
    MGPLLARLGH AKVAMPGGCA IGSRPIDLHL KGLNALGAEI ERHDGYVEAT 150
    ANQLHGAAIY LDFPSVGATQ NIMMAATLAD GITTMENVAR EPEIVDLANY 200
    LNQMGAKVTG AGTETIRIEG VKAMHGCDHS IVQDRIEAGT FMVAAAVTQG 250
    NVLVEDAIAE HNKPLISKMR EMGVTVTEEP AGIRVIGPEI LKPTSVKTMP 300
    HPGFPTDMQP QMTILQLCAQ GTSLLTETVF ENRFMHLDEL RRMNADFKVE 350
    GRSVIMYGPT DFNGAQVTAT DLRAAAALVI AGLVSRGYTE VTNLKYLDRG 400
    YFNFHGKLAK LGAEIKRVDV PDGTVYALNP DFANEAAE 438
    Length:438
    Mass (Da):47,147
    Last modified:June 1, 2003 - v1
    Checksum:iE48B4C5686B3A8AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79550.1.
    RefSeqiYP_004890064.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC79550; CCC79550; lp_2361.
    GeneIDi1062393.
    KEGGilpl:lp_2361.
    PATRICi22250759. VBILacPla27411_1995.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC79550.1 .
    RefSeqi YP_004890064.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali Q88UU5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_2361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC79550 ; CCC79550 ; lp_2361 .
    GeneIDi 1062393.
    KEGGi lpl:lp_2361.
    PATRICi 22250759. VBILacPla27411_1995.

    Phylogenomic databases

    eggNOGi COG0766.
    HOGENOMi HOG000075602.
    KOi K00790.
    OMAi VTDIYHI.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci LPLA220668-WGS:GSPK-2034-MONOMER.

    Family and domain databases

    Gene3Di 3.65.10.10. 2 hits.
    HAMAPi MF_00111. MurA.
    InterProi IPR001986. Enolpyruvate_Tfrase_dom.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR005750. UDP_GlcNAc_COvinyl_MurA.
    [Graphical view ]
    PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
    Pfami PF00275. EPSP_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR01072. murA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiMURA1_LACPL
    AccessioniPrimary (citable) accession number: Q88UU5
    Secondary accession number(s): F9UQR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3