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Q88U30

- PUR2_LACPL

UniProt

Q88U30 - PUR2_LACPL

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Protein

Phosphoribosylamine--glycine ligase

Gene
purD, lp_2719
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi279 – 2791Magnesium or manganese By similarity
Metal bindingi281 – 2811Magnesium or manganese By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi135 – 19056ATP By similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-2325-MONOMER.
UniPathwayiUPA00074; UER00125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligase (EC:6.3.4.13)
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene namesi
Name:purD
Ordered Locus Names:lp_2719
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Phosphoribosylamine--glycine ligaseUniRule annotationPRO_0000151456Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_2719.

Structurei

3D structure databases

ProteinModelPortaliQ88U30.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 309201ATP-graspAdd
BLAST

Sequence similaritiesi

Belongs to the GARS family.
Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0151.
HOGENOMiHOG000033463.
KOiK01945.
OMAiCIAGLKN.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPiMF_00138. GARS.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88U30-1 [UniParc]FASTAAdd to Basket

« Hide

MANVLVVGGG GREHAIAKAM MASPQVSTVY CAPGNPGMIR DGIRTLAIDE    50
MDFAGLVNFA RANTVTLTFV GPEVPLAAGI VDYFQAAGLA IFGPNQAAAQ 100
LESSKVFAKA FMSRHHIPTA DYRQFHELDS ALAYSHEQAV PQVIKVDGLA 150
AGKGVTVATS HEQAAAAIKT AFKTSSTVLI EDYVAGFEFS QMVLVGGEHY 200
ALLPTAQDHK RLQDHDRGPN TGGMGAYSPV PQITPAVIDQ TIATIIEPTI 250
AGLKADGLSF EGVIYVGGIL TATGVQVIEY NLRLGDPETQ ILLPQLQSDF 300
YQVIVDLLQH RQPHAQWQTT ATYLGVVLAA PGYPGPTEAG VPVPTVAGAD 350
YASVAGTPDQ LVSAGGRVMM VTASAPSLVA AQRAVYQQID QLRVGDLVYR 400
TDIGAKGMTA THD 413
Length:413
Mass (Da):43,463
Last modified:June 1, 2003 - v1
Checksum:i10AE0CDB704F08FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79834.1.
RefSeqiWP_011101891.1. NC_004567.2.
YP_004890348.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79834; CCC79834; lp_2719.
GeneIDi1063006.
KEGGilpl:lp_2719.
PATRICi22251333. VBILacPla27411_2274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC79834.1 .
RefSeqi WP_011101891.1. NC_004567.2.
YP_004890348.1. NC_004567.2.

3D structure databases

ProteinModelPortali Q88U30.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_2719.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC79834 ; CCC79834 ; lp_2719 .
GeneIDi 1063006.
KEGGi lpl:lp_2719.
PATRICi 22251333. VBILacPla27411_2274.

Phylogenomic databases

eggNOGi COG0151.
HOGENOMi HOG000033463.
KOi K01945.
OMAi CIAGLKN.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00125 .
BioCyci LPLA220668-WGS:GSPK-2325-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPi MF_00138. GARS.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00877. purD. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiPUR2_LACPL
AccessioniPrimary (citable) accession number: Q88U30
Secondary accession number(s): F9URJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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