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Q88U30 (PUR2_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:lp_2719
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151456

Regions

Domain109 – 309201ATP-grasp
Nucleotide binding135 – 19056ATP By similarity

Sites

Metal binding2791Magnesium or manganese By similarity
Metal binding2811Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88U30 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 10AE0CDB704F08FF

FASTA41343,463
        10         20         30         40         50         60 
MANVLVVGGG GREHAIAKAM MASPQVSTVY CAPGNPGMIR DGIRTLAIDE MDFAGLVNFA 

        70         80         90        100        110        120 
RANTVTLTFV GPEVPLAAGI VDYFQAAGLA IFGPNQAAAQ LESSKVFAKA FMSRHHIPTA 

       130        140        150        160        170        180 
DYRQFHELDS ALAYSHEQAV PQVIKVDGLA AGKGVTVATS HEQAAAAIKT AFKTSSTVLI 

       190        200        210        220        230        240 
EDYVAGFEFS QMVLVGGEHY ALLPTAQDHK RLQDHDRGPN TGGMGAYSPV PQITPAVIDQ 

       250        260        270        280        290        300 
TIATIIEPTI AGLKADGLSF EGVIYVGGIL TATGVQVIEY NLRLGDPETQ ILLPQLQSDF 

       310        320        330        340        350        360 
YQVIVDLLQH RQPHAQWQTT ATYLGVVLAA PGYPGPTEAG VPVPTVAGAD YASVAGTPDQ 

       370        380        390        400        410 
LVSAGGRVMM VTASAPSLVA AQRAVYQQID QLRVGDLVYR TDIGAKGMTA THD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC79834.1.
RefSeqYP_004890348.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ88U30.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_2719.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC79834; CCC79834; lp_2719.
GeneID1063006.
KEGGlpl:lp_2719.
PATRIC22251333. VBILacPla27411_2274.

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMADPEAMNV.
ProtClustDBCLSK2520478.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_LACPL
AccessionPrimary (citable) accession number: Q88U30
Secondary accession number(s): F9URJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways