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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciLPLA220668:G137Z-2316-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:lp_2720
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001920971 – 510Bifunctional purine biosynthesis protein PurHAdd BLAST510

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_2720.

Structurei

3D structure databases

ProteinModelPortaliQ88U29.
SMRiQ88U29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC1. Bacteria.
COG0138. LUCA.
HOGENOMiHOG000230373.
KOiK00602.
OMAiDLLFAWK.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH. 1 hit.
InterProiView protein in InterPro
IPR024051. AICAR_Tfase_dup_dom_sf.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
IPR036914. MGS-like_dom_sf.
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiView protein in Pfam
PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiView protein in SMART
SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88U29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKRALLSVS DKQGLTDFAK GLVALDYELI STGGTKKALE AADIPVIGIE
60 70 80 90 100
EVTGFPEMLD GRVKTLHPKV HAGLLARRDL PAHMAQLKAA GIQPIDMVVV
110 120 130 140 150
NLYPFKATIQ QPDVTQAEAI EQIDIGGPSM LRSAAKNFAA VLPIVDPADY
160 170 180 190 200
EQILADLQTD AVTPALRQRL AAKVFQHTAA YDALIAQYLT TEEFPEKLTL
210 220 230 240 250
TYDKKQALRY GENSHQKAAF YENALPTHFS ITGAKQIHGK ELSYNNIKDA
260 270 280 290 300
DAALRMVSEY QQPAVVAMKH MNPCGVGLGT TIEAAWDKAY EADSISIFGG
310 320 330 340 350
IIALNRPVDL ATAEKMHALF LEIIIAPSFD DDAFAILAKK KNLRLMTVDF
360 370 380 390 400
EQTHTADKFE TISVGGGLLR QEVDAAFETP ADFTVVTVTQ PTPAQLKALA
410 420 430 440 450
FGQQVVKHVK SNAVVVTTAD RTLGIGSGQM NRIDSTKIAI GKAMKQAGYE
460 470 480 490 500
NAILASDAFF PMDDCVEYAA QHGIRAIVQP GGSIRDKDSI AMADRYGIAM
510
VTTGVRHFRH
Length:510
Mass (Da):55,306
Last modified:June 20, 2003 - v1
Checksum:i6054866F95DD0CBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC79835.1.
RefSeqiWP_011101892.1. NC_004567.2.
YP_004890349.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC79835; CCC79835; lp_2720.
GeneIDi1063024.
KEGGilpl:lp_2720.
PATRICifig|220668.9.peg.2275.

Similar proteinsi

Entry informationi

Entry nameiPUR9_LACPL
AccessioniPrimary (citable) accession number: Q88U29
Secondary accession number(s): F9URJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families