Reviewed, UniProtKB/Swiss-Prot Q88T35 (GPMA2_LACPL)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2
      Short name=Phosphoglyceromutase 2
      Short name=PGAM 2
      Short name=BPG-dependent PGAM 2
      Short name=dPGM 2
    EC=5.4.2.1

Gene names

Name:	gpmA2
Synonyms:	pmg9
Ordered Locus Names:	lp_3170

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 HAMAP MF_01039		PRO_0000179887
Sites
	Active site	9	1	Tele-phosphohistidine intermediate By similarity
	Active site	182	1	By similarity
	Site	60	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88T35-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 48F3904EEB2E142D	FASTA	230	26,087
	10 20 30 40 50 60 MAKLVLIRHG QSEWNLSNQF TGWVDVDLSE KGVEEAKAAG QKVKEAGLEF DYAFTSVLTR 70 80 90 100 110 120 AIKTLHYVLE ESDQLWIPET KTWRLNERHY GALQGLNKKE TAEKYGDDQV HIWRRSYDVL 130 140 150 160 170 180 PPLLSADDEG SAVNDRRYAD LDPNIVPGGE NLKVTLERVM PFWEDQIAPK LLDGKNVIIA 190 200 210 220 230 AHGNSLRALS KYIEQISDDD IMDLEMATGE PVVYDFDEKL KVLGKEKLGK

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935261 Genomic DNA. Translation: CAD65323.1.
RefSeq	NP_786452.1.
3D structure databases
HSSP	HSSP built from PDB template 1E58 based on UniProtKB P31217.
ModBase	Search...
Genome annotation databases
GeneID	1063992.
GenomeReviews	Gene locus lp_3170 in contig AL935263_GR.
KEGG	lpl:lp_3170.
NMPDR	fig|220668.1.peg.2586.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88T35.
OMA	FMLWRRS.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_3170-MON.
BRENDA	5.4.2.1. 593.
Family and domain databases
HAMAP	MF_01039. [Tree]
InterPro	IPR001345. PG/BPGM_mutase_AC. IPR013078. PG_mutase. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA2_LACPL

Accession

Primary (citable) accession number: Q88T35

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)