Q88SR1 (ADEC_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2

Gene names

Name:	ade
Synonyms:	adeC
Ordered Locus Names:	lp_3334

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity. HAMAP MF_01518
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 563	563	Adenine deaminase HAMAP MF_01518		PRO_0000142426

Sequences

	Sequence		Length	Mass (Da)
	Q88SR1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A4B5159C11718FA7	FASTA	563	60,927
	10 20 30 40 50 60 MTKTVEMVIT GAQVLNVYTR EFEATSLWID HGRIISNLRD EPYIAAQHVD ATGQWIVPGM 70 80 90 100 110 120 IDAHVHMESS MVAPSELGKV LLQHGVTTIA TDPHELANVA GIAGIQYLID DARQTPLDVC 130 140 150 160 170 180 FMLPSSVPCV PFDDNGATLH AADLRPLYQQ SEVRGLAEVM DYGAVARGDT DTLAKISDAY 190 200 210 220 230 240 AYGYHADGHA AGLNAHQLNV MRNAGLDTDH ECMTVAEAQD RVRAGMAVFL REGTVERDVL 250 260 270 280 290 300 PTIGAVTEAN ASRFAFCTDD KMISDLLTEG SIDYNVRLAM QSGMRPELAY TLASLNGAMA 310 320 330 340 350 360 HRLSDRGSLS AGQLADLVVL DDLEHVRIAR TMKRGQWILP STTKPLPFTA TRVQHHAQLA 370 380 390 400 410 420 DFQLPLATGL ANVIGVQPNH IETDHLTLPI DATQNFEADC QRDILKMVVI ERHHNTGKVG 430 440 450 460 470 480 VGLVHGFALK QGAIAGTVAH DAHNIVAVGT SDAAILRAVA QITQDNGGIA VVDNEQVLAT 490 500 510 520 530 540 MPLAIGGLLS AASYQKVAEQ LAELKRAYEV ISERPLSFDP FITLSFLTLP VIPTLKLTAR 550 560 GLFDYATFDF IPVAIQDNQR QTV

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC80327.1.
RefSeq	NP_786577.1. NC_004567.1.
3D structure databases
ProteinModelPortal	Q88SR1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1063932.
GenomeReviews	Gene locus lp_3334 in contig AL935263_GR.
KEGG	lpl:lp_3334.
NMPDR	fig|220668.1.peg.2711.
PATRIC	22252359. VBILacPla27411_2779.
Phylogenomic databases
HOGENOM	HBG725357.
OMA	GKIITEH.
ProtClustDB	CLSK2520615.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_3334-MONOMER.
Family and domain databases
HAMAP	MF_01518. Adenine_deamin. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01486.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01178. Ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_LACPL

Accession

Primary (citable) accession number: Q88SR1
Secondary accession number(s): F9UTK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program