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Q88SK7

- UPPP_LACPL

UniProt

Q88SK7 - UPPP_LACPL

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (20 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-2875-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:lp_3407
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Undecaprenyl-diphosphatasePRO_0000151159Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi220668.lp_3407.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalUniRule annotationAdd
    BLAST
    Transmembranei43 – 6321HelicalUniRule annotationAdd
    BLAST
    Transmembranei83 – 10321HelicalUniRule annotationAdd
    BLAST
    Transmembranei111 – 13121HelicalUniRule annotationAdd
    BLAST
    Transmembranei147 – 16721HelicalUniRule annotationAdd
    BLAST
    Transmembranei186 – 20621HelicalUniRule annotationAdd
    BLAST
    Transmembranei221 – 24121HelicalUniRule annotationAdd
    BLAST
    Transmembranei255 – 27521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFMNMFEY.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88SK7-1 [UniParc]FASTAAdd to Basket

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    MLDIFKAVIL GIVEGITEFL PISSTGHLVL VDEFIKMQQS TQFTDMFNVV    50
    IQLGAIMAVV VLYFHKLNPL SPRKDTTEKR NTWVLWSKVL LAVIPSVIVG 100
    LPLNDWMDEH LMNWAVVSAT LIIYGVLFIV IENHNKRLTP RFANLQTLPY 150
    TTALFIGCFQ LLSLIPGTSR SGATILGAIL IGTSRYVATE FSFFMAIPTM 200
    FGASLLKLVK FFAHGGSLAG LQGAVLAVGV IVSFVVAYLS IRFLLDYIKK 250
    NDFKAFGWYR IVLGVLVIGY FTLIH 275
    Length:275
    Mass (Da):30,552
    Last modified:June 20, 2003 - v1
    Checksum:iDCC524DD6CD57631
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC80388.1.
    RefSeqiYP_004890902.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC80388; CCC80388; lp_3407.
    GeneIDi1063763.
    KEGGilpl:lp_3407.
    PATRICi22252476. VBILacPla27411_2837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC80388.1 .
    RefSeqi YP_004890902.1. NC_004567.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_3407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC80388 ; CCC80388 ; lp_3407 .
    GeneIDi 1063763.
    KEGGi lpl:lp_3407.
    PATRICi 22252476. VBILacPla27411_2837.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FMNMFEY.

    Enzyme and pathway databases

    BioCyci LPLA220668-WGS:GSPK-2875-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiUPPP_LACPL
    AccessioniPrimary (citable) accession number: Q88SK7
    Secondary accession number(s): F9UU86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: June 20, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3