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Q88SK7 (UPPP_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:lp_3407
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151159

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q88SK7 [UniParc].

Last modified June 20, 2003. Version 1.
Checksum: DCC524DD6CD57631

FASTA27530,552
        10         20         30         40         50         60 
MLDIFKAVIL GIVEGITEFL PISSTGHLVL VDEFIKMQQS TQFTDMFNVV IQLGAIMAVV 

        70         80         90        100        110        120 
VLYFHKLNPL SPRKDTTEKR NTWVLWSKVL LAVIPSVIVG LPLNDWMDEH LMNWAVVSAT 

       130        140        150        160        170        180 
LIIYGVLFIV IENHNKRLTP RFANLQTLPY TTALFIGCFQ LLSLIPGTSR SGATILGAIL 

       190        200        210        220        230        240 
IGTSRYVATE FSFFMAIPTM FGASLLKLVK FFAHGGSLAG LQGAVLAVGV IVSFVVAYLS 

       250        260        270 
IRFLLDYIKK NDFKAFGWYR IVLGVLVIGY FTLIH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC80388.1.
RefSeqYP_004890902.1. NC_004567.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_3407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC80388; CCC80388; lp_3407.
GeneID1063763.
KEGGlpl:lp_3407.
PATRIC22252476. VBILacPla27411_2837.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
ProtClustDBPRK00281.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_LACPL
AccessionPrimary (citable) accession number: Q88SK7
Secondary accession number(s): F9UU86
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families