Reviewed, UniProtKB/Swiss-Prot Q88SE8 (GAL1_LACPL)

Names and origin

Protein names

Recommended name:
    Galactokinase
    EC=2.7.1.6
Alternative name(s):
    Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	lp_3482

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate phosphorylation Inferred from electronic annotation. Source: InterPro galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP galactokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Galactokinase HAMAP MF_00246		PRO_0000184617
Regions
	Nucleotide binding	122 – 132	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q88SE8-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E6DCB3FB8EEA0D66	FASTA	387	42,646
	10 20 30 40 50 60 MNTSDLKQEF TEAFDTKPER VFFSPGRINL IGEHTDYNGG HVFPCAITIG TYGVYAPRTD 70 80 90 100 110 120 TTVRMYSANI PDAGIVTFDV NDLSYDKAAG WTNYPKGMMD EIAKTGVKFD HGFDFYVHGN 130 140 150 160 170 180 MPDGAGLSSS ASIELLTGIM LNTGFNLGIS QLDLVKIGQK CENNYVGVNS GIMDQFAVGM 190 200 210 220 230 240 GKKDQAILLD TNTMDYSYAP VKLGNNVIVI MNTNKRRELA DSKYNERRSE CEEALRRLQT 250 260 270 280 290 300 KLDIKSLGDL TNDQFDEAAY LINDETLIKR ARHAVFENQR AIRATKALAD DDLTTFGELV 310 320 330 340 350 360 TASHVSLHFD YEVTGKELDT LAETAWKQPG VLGARMTGAG FGGCGIAIVD KDQVDAFKEN 370 380 VGKVYRDTIG YDADFYIAEI ADGPKEL

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935262 Genomic DNA. Translation: CAD65568.1.
RefSeq	NP_786690.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1063392.
GenomeReviews	Gene locus lp_3482 in contig AL935263_GR.
KEGG	lpl:lp_3482.
NMPDR	fig|220668.1.peg.2824.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88SE8.
OMA	Q88SE8. YNDGFVM.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_3482-MON.
BRENDA	2.7.1.6. 593.
Family and domain databases
HAMAP	MF_00246. [Tree]
InterPro	IPR000705. Galactokinase. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal_bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00131. gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_LACPL

Accession

Primary (citable) accession number: Q88SE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)