Q88S84 (ARAA_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	lp_3554

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	L-arabinose isomerase HAMAP MF_00519		PRO_0000312610
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88S84 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 4093B8829B136C49	FASTA	474	53,573
	10 20 30 40 50 60 MLSVPDYEFW FVTGSQHLYG EEQLKSVAKD AQDIADKLNA SGKLPYKVVF KDVMTTAESI 70 80 90 100 110 120 TNFMKEVNYN DKVAGVITWM HTFSPAKNWI RGTELLQKPL LHLATQYLNN IPYADIDFDY 130 140 150 160 170 180 MNLNQSAHGD REYAYINARL QKHNKIVYGY WGDEDVQEQI ARWEDVAVAY NESFKVKVAR 190 200 210 220 230 240 FGDTMRNVAV TEGDKVEAQI KMGWTVDYYG IGDLVEEINK VSDADVDKEY ADLESRYEMV 250 260 270 280 290 300 QGDNDADTYK HSVRVQLAQY LGIKRFLERG GYTAFTTNFE DLWGMEQLPG LASQLLIRDG 310 320 330 340 350 360 YGFGAEGDWK TAALGRVMKI MSHNKQTAFM EDYTLDLRHG HEAILGSHML EVDPSIASDK 370 380 390 400 410 420 PRVEVHPLDI GGKDDPARLV FTGSEGEAID VTVADFRDGF KMISYAVDAN KPEAETPNLP 430 440 450 460 470 VAKQLWTPKM GLKKGALEWM QAGGGHHTML SFSLTEEQME DYATMVGMTK AFLK

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC80517.1.
RefSeq	NP_786756.1. NC_004567.1.
3D structure databases
HSSP	HSSP built from PDB template 2AJT based on UniProtKB P08202.
ProteinModelPortal	Q88S84.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1061986.
GenomeReviews	Gene locus lp_3554 in contig AL935263_GR.
KEGG	lpl:lp_3554.
NMPDR	fig|220668.1.peg.2890.
PATRIC	22252732. VBILacPla27411_2964.
Phylogenomic databases
HOGENOM	HBG297198.
OMA	DVAVAYN.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_3554-MONOMER.
BRENDA	5.3.1.4. 2888.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_LACPL

Accession

Primary (citable) accession number: Q88S84
Secondary accession number(s): F9ULB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program