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Q88S38

- IOLG_LACPL

UniProt

Q88S38 - IOLG_LACPL

Protein

Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

Gene

iolG

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.UniRule annotation

    Catalytic activityi

    Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation
    1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. inositol 2-dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-3054-MONOMER.
    UniPathwayiUPA00076; UER00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation, EC:1.1.1.369UniRule annotation)
    Alternative name(s):
    Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation
    Short name:
    MI 2-dehydrogenase/DCI 3-dehydrogenaseUniRule annotation
    Gene namesi
    Name:iolGUniRule annotation
    Ordered Locus Names:lp_3606
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenasePRO_0000352573Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi220668.lp_3606.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88S38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Gfo/Idh/MocA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0673.
    HOGENOMiHOG000227439.
    KOiK00010.
    OMAiCFCEKPL.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01671. IolG.
    InterProiIPR023794. MI/DCI_dehydrogenase.
    IPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    IPR004104. OxRdtase_C.
    [Graphical view]
    PfamiPF01408. GFO_IDH_MocA. 1 hit.
    PF02894. GFO_IDH_MocA_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q88S38-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEAHVTKVG IVGIGFIGSD HLHRLTKTVA NVDVTAVCDI VPGKAQKALD    50
    QQGLTATTYE DYHDLVNDPN VEVVVCTANN EAHYEIVMAA LKAGKFTFCE 100
    KPLALDAKQC MDIIDSEKKL GRRMLQVGFM RHYAPEYVQM KKMIDDGVIG 150
    KPLMMDQRHY NQTQPEEYDS SRSIIETAIH EIDIDHWLVN DDYANIRVFS 200
    PKQTRHVQNA KIQDPQIVMI ETKSGINIIN EVFVRCQYGY DIKCDVIGEE 250
    GVLELPTVPQ VATRLNAQYS TAILTDWKAR FESAYDIEFR DFINHVSQNE 300
    SPVGPSAWDG YIAAVTADAA LKSLAEDGAK QDLDFPSTPA FYTESEKVSE 350
    Length:350
    Mass (Da):39,180
    Last modified:June 1, 2003 - v1
    Checksum:iB17862B12C4514DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC80567.1.
    RefSeqiWP_011102248.1. NC_004567.2.
    YP_004891081.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC80567; CCC80567; lp_3606.
    GeneIDi1062111.
    KEGGilpl:lp_3606.
    PATRICi22252824. VBILacPla27411_3010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC80567.1 .
    RefSeqi WP_011102248.1. NC_004567.2.
    YP_004891081.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali Q88S38.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_3606.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC80567 ; CCC80567 ; lp_3606 .
    GeneIDi 1062111.
    KEGGi lpl:lp_3606.
    PATRICi 22252824. VBILacPla27411_3010.

    Phylogenomic databases

    eggNOGi COG0673.
    HOGENOMi HOG000227439.
    KOi K00010.
    OMAi CFCEKPL.

    Enzyme and pathway databases

    UniPathwayi UPA00076 ; UER00143 .
    BioCyci LPLA220668-WGS:GSPK-3054-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01671. IolG.
    InterProi IPR023794. MI/DCI_dehydrogenase.
    IPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    IPR004104. OxRdtase_C.
    [Graphical view ]
    Pfami PF01408. GFO_IDH_MocA. 1 hit.
    PF02894. GFO_IDH_MocA_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiIOLG_LACPL
    AccessioniPrimary (citable) accession number: Q88S38
    Secondary accession number(s): F9ULG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3