Reviewed, UniProtKB/Swiss-Prot Q88S38 (IOLG_LACPL)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
    EC=1.1.1.18
    EC=1.1.1.n6
Alternative name(s):
    Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
      Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	lp_3606

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671		PRO_0000352573

Sequences

	Sequence		Length	Mass (Da)
	Q88S38-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B17862B12C4514DD	FASTA	350	39,180
	10 20 30 40 50 60 MAEAHVTKVG IVGIGFIGSD HLHRLTKTVA NVDVTAVCDI VPGKAQKALD QQGLTATTYE 70 80 90 100 110 120 DYHDLVNDPN VEVVVCTANN EAHYEIVMAA LKAGKFTFCE KPLALDAKQC MDIIDSEKKL 130 140 150 160 170 180 GRRMLQVGFM RHYAPEYVQM KKMIDDGVIG KPLMMDQRHY NQTQPEEYDS SRSIIETAIH 190 200 210 220 230 240 EIDIDHWLVN DDYANIRVFS PKQTRHVQNA KIQDPQIVMI ETKSGINIIN EVFVRCQYGY 250 260 270 280 290 300 DIKCDVIGEE GVLELPTVPQ VATRLNAQYS TAILTDWKAR FESAYDIEFR DFINHVSQNE 310 320 330 340 350 SPVGPSAWDG YIAAVTADAA LKSLAEDGAK QDLDFPSTPA FYTESEKVSE

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935262 Genomic DNA. Translation: CAD65683.1.
RefSeq	NP_786805.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1062111.
GenomeReviews	Gene locus lp_3606 in contig AL935263_GR.
KEGG	lpl:lp_3606.
NMPDR	fig|220668.1.peg.2939.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88S38.
OMA	DWKDRFI.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_3606-MONOMER.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_LACPL

Accession

Primary (citable) accession number: Q88S38

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)