Q88S38 (IOLG_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
EC=1.1.1.18
EC=1.1.1.n6

Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	lp_3606

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671		PRO_0000352573

Sequences

	Sequence		Length	Mass (Da)
	Q88S38 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B17862B12C4514DD	FASTA	350	39,180
	10 20 30 40 50 60 MAEAHVTKVG IVGIGFIGSD HLHRLTKTVA NVDVTAVCDI VPGKAQKALD QQGLTATTYE 70 80 90 100 110 120 DYHDLVNDPN VEVVVCTANN EAHYEIVMAA LKAGKFTFCE KPLALDAKQC MDIIDSEKKL 130 140 150 160 170 180 GRRMLQVGFM RHYAPEYVQM KKMIDDGVIG KPLMMDQRHY NQTQPEEYDS SRSIIETAIH 190 200 210 220 230 240 EIDIDHWLVN DDYANIRVFS PKQTRHVQNA KIQDPQIVMI ETKSGINIIN EVFVRCQYGY 250 260 270 280 290 300 DIKCDVIGEE GVLELPTVPQ VATRLNAQYS TAILTDWKAR FESAYDIEFR DFINHVSQNE 310 320 330 340 350 SPVGPSAWDG YIAAVTADAA LKSLAEDGAK QDLDFPSTPA FYTESEKVSE

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC80567.1.
RefSeq	NP_786805.1. NC_004567.1.
3D structure databases
ProteinModelPortal	Q88S38.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1062111.
GenomeReviews	Gene locus lp_3606 in contig AL935263_GR.
KEGG	lpl:lp_3606.
NMPDR	fig|220668.1.peg.2939.
PATRIC	22252824. VBILacPla27411_3010.
Phylogenomic databases
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK894854.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_3606-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_LACPL

Accession

Primary (citable) accession number: Q88S38
Secondary accession number(s): F9ULG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program