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Reviewed, UniProtKB/Swiss-Prot Q88S38 (IOLG_LACPL)

Last modified November 3, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
    EC=1.1.1.18
    EC=1.1.1.n6
Alternative name(s):
    Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
      Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase
Gene names
Name: iolG
Ordered Locus Names: lp_3606
OrganismLactobacillus plantarum [Complete proteome] [HAMAP]
Taxonomic identifier1590 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity.

Catalytic activity

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671

D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the gfo/idh/mocA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671
PRO_0000352573

Sequences

Sequence LengthMass (Da)Tools
Q88S38-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B17862B12C4514DD

FASTA35039,180
        10         20         30         40         50         60 
MAEAHVTKVG IVGIGFIGSD HLHRLTKTVA NVDVTAVCDI VPGKAQKALD QQGLTATTYE 

        70         80         90        100        110        120 
DYHDLVNDPN VEVVVCTANN EAHYEIVMAA LKAGKFTFCE KPLALDAKQC MDIIDSEKKL 

       130        140        150        160        170        180 
GRRMLQVGFM RHYAPEYVQM KKMIDDGVIG KPLMMDQRHY NQTQPEEYDS SRSIIETAIH 

       190        200        210        220        230        240 
EIDIDHWLVN DDYANIRVFS PKQTRHVQNA KIQDPQIVMI ETKSGINIIN EVFVRCQYGY 

       250        260        270        280        290        300 
DIKCDVIGEE GVLELPTVPQ VATRLNAQYS TAILTDWKAR FESAYDIEFR DFINHVSQNE 

       310        320        330        340        350 
SPVGPSAWDG YIAAVTADAA LKSLAEDGAK QDLDFPSTPA FYTESEKVSE 

« Hide

Cross-references

Sequence databases

AL935262 Genomic DNA. Translation: CAD65683.1.
RefSeqNP_786805.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1062111.
GenomeReviewsGene locus lp_3606 in contig AL935263_GR.
KEGGlpl:lp_3606.
NMPDRfig|220668.1.peg.2939.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ88S38.
OMADWKDRFI.

Enzyme and pathway databases

BioCycLPLA220668:LP_3606-MONOMER.

Family and domain databases

HAMAPMF_01671.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLG_LACPL
AccessionPrimary (citable) accession number: Q88S38
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 1, 2003
Last modified: November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents