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Q88S38 (IOLG_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

EC=1.1.1.18
EC=1.1.1.369
Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase
Gene names
Name:iolG
Ordered Locus Names:lp_3606
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP-Rule MF_01671

Catalytic activity

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP-Rule MF_01671

1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP-Rule MF_01671

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP-Rule MF_01671

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01671

Sequence similarities

Belongs to the Gfo/Idh/MocA family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinositol catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioninositol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP-Rule MF_01671
PRO_0000352573

Sequences

Sequence LengthMass (Da)Tools
Q88S38 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B17862B12C4514DD

FASTA35039,180
        10         20         30         40         50         60 
MAEAHVTKVG IVGIGFIGSD HLHRLTKTVA NVDVTAVCDI VPGKAQKALD QQGLTATTYE 

        70         80         90        100        110        120 
DYHDLVNDPN VEVVVCTANN EAHYEIVMAA LKAGKFTFCE KPLALDAKQC MDIIDSEKKL 

       130        140        150        160        170        180 
GRRMLQVGFM RHYAPEYVQM KKMIDDGVIG KPLMMDQRHY NQTQPEEYDS SRSIIETAIH 

       190        200        210        220        230        240 
EIDIDHWLVN DDYANIRVFS PKQTRHVQNA KIQDPQIVMI ETKSGINIIN EVFVRCQYGY 

       250        260        270        280        290        300 
DIKCDVIGEE GVLELPTVPQ VATRLNAQYS TAILTDWKAR FESAYDIEFR DFINHVSQNE 

       310        320        330        340        350 
SPVGPSAWDG YIAAVTADAA LKSLAEDGAK QDLDFPSTPA FYTESEKVSE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC80567.1.
RefSeqYP_004891081.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ88S38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_3606.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC80567; CCC80567; lp_3606.
GeneID1062111.
KEGGlpl:lp_3606.
PATRIC22252824. VBILacPla27411_3010.

Phylogenomic databases

eggNOGCOG0673.
HOGENOMHOG000227439.
KOK00010.
OMAGRMGADH.
ProtClustDBCLSK894854.

Enzyme and pathway databases

UniPathwayUPA00076; UER00143.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01671. IolG.
InterProIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLG_LACPL
AccessionPrimary (citable) accession number: Q88S38
Secondary accession number(s): F9ULG0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways