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Protein

Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

Gene

iolG

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation
1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. inositol 2-dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-3054-MONOMER.
UniPathwayiUPA00076; UER00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation, EC:1.1.1.369UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenase/DCI 3-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:lp_3606
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenasePRO_0000352573Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi220668.lp_3606.

Structurei

3D structure databases

ProteinModelPortaliQ88S38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000227439.
KOiK00010.
OMAiSHDSTHA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88S38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAHVTKVG IVGIGFIGSD HLHRLTKTVA NVDVTAVCDI VPGKAQKALD
60 70 80 90 100
QQGLTATTYE DYHDLVNDPN VEVVVCTANN EAHYEIVMAA LKAGKFTFCE
110 120 130 140 150
KPLALDAKQC MDIIDSEKKL GRRMLQVGFM RHYAPEYVQM KKMIDDGVIG
160 170 180 190 200
KPLMMDQRHY NQTQPEEYDS SRSIIETAIH EIDIDHWLVN DDYANIRVFS
210 220 230 240 250
PKQTRHVQNA KIQDPQIVMI ETKSGINIIN EVFVRCQYGY DIKCDVIGEE
260 270 280 290 300
GVLELPTVPQ VATRLNAQYS TAILTDWKAR FESAYDIEFR DFINHVSQNE
310 320 330 340 350
SPVGPSAWDG YIAAVTADAA LKSLAEDGAK QDLDFPSTPA FYTESEKVSE
Length:350
Mass (Da):39,180
Last modified:June 1, 2003 - v1
Checksum:iB17862B12C4514DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC80567.1.
RefSeqiYP_004891081.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC80567; CCC80567; lp_3606.
GeneIDi1062111.
KEGGilpl:lp_3606.
PATRICi22252824. VBILacPla27411_3010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC80567.1.
RefSeqiYP_004891081.1. NC_004567.2.

3D structure databases

ProteinModelPortaliQ88S38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220668.lp_3606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCC80567; CCC80567; lp_3606.
GeneIDi1062111.
KEGGilpl:lp_3606.
PATRICi22252824. VBILacPla27411_3010.

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000227439.
KOiK00010.
OMAiSHDSTHA.

Enzyme and pathway databases

UniPathwayiUPA00076; UER00143.
BioCyciLPLA220668-WGS:GSPK-3054-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiIOLG_LACPL
AccessioniPrimary (citable) accession number: Q88S38
Secondary accession number(s): F9ULG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.