Q88S38 (IOLG_LACPL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 49.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase EC=1.1.1.18 EC=1.1.1.n6 Alternative name(s): Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase | ||||
| Gene names |
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| Organism | Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) | ||||
| Taxonomic identifier | 220668 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus |
Protein attributes
| Sequence length | 350 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP MF_01671 |
| Catalytic activity | Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 |
| Pathway | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_01671 |
| Sequence similarities | Belongs to the gfo/idh/mocA family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | inositol catabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 350 | 350 | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671 | PRO_0000352573 | |||
Sequences
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References
| [1] | "Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL935263 Genomic DNA. Translation: CCC80567.1. |
| RefSeq | NP_786805.1. NC_004567.1. |
3D structure databases | |
| ProteinModelPortal | Q88S38. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1062111. |
| GenomeReviews | Gene locus lp_3606 in contig AL935263_GR. |
| KEGG | lpl:lp_3606. |
| NMPDR | fig|220668.1.peg.2939. |
| PATRIC | 22252824. VBILacPla27411_3010. |
Phylogenomic databases | |
| HOGENOM | HBG612336. |
| OMA | YDVELQD. |
| ProtClustDB | CLSK894854. |
Enzyme and pathway databases | |
| BioCyc | LPLA220668:LP_3606-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01671. IolG. [Tree] |
| InterPro | IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00010. |
| PANTHER | PTHR22604:SF7. PTHR22604:SF7. 1 hit. |
| Pfam | PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IOLG_LACPL | ||||||||
| Accession | Primary (citable) accession number: Q88S38 Secondary accession number(s): F9ULG0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with