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Protein

Inosose dehydratase

Gene

iolE

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase (iolG)
  2. Inosose dehydratase (iolE)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. no protein annotated in this organism
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandCobalt, Manganese

Enzyme and pathway databases

BioCyciLPLA220668:G1GW0-3055-MONOMER
UniPathwayiUPA00076; UER00144

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:lp_3607
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523741 – 300Inosose dehydrataseAdd BLAST300

Proteomic databases

PRIDEiQ88S37

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_3607

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 7Combined sources5
Beta strandi9 – 13Combined sources5
Helixi15 – 17Combined sources3
Beta strandi21 – 23Combined sources3
Turni24 – 29Combined sources6
Helixi32 – 42Combined sources11
Helixi56 – 65Combined sources10
Beta strandi72 – 77Combined sources6
Helixi79 – 100Combined sources22
Beta strandi105 – 110Combined sources6
Turni123 – 125Combined sources3
Helixi132 – 151Combined sources20
Beta strandi155 – 159Combined sources5
Beta strandi164 – 166Combined sources3
Helixi169 – 177Combined sources9
Turni181 – 183Combined sources3
Beta strandi185 – 189Combined sources5
Helixi190 – 197Combined sources8
Helixi201 – 207Combined sources7
Helixi208 – 210Combined sources3
Beta strandi211 – 216Combined sources6
Helixi221 – 230Combined sources10
Helixi234 – 239Combined sources6
Turni246 – 248Combined sources3
Helixi254 – 262Combined sources9
Beta strandi267 – 271Combined sources5
Turni277 – 279Combined sources3
Helixi282 – 296Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CNYX-ray1.85A/B1-300[»]
ProteinModelPortaliQ88S37
SMRiQ88S37
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ88S37

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJK Bacteria
COG1082 LUCA
HOGENOMiHOG000239720
KOiK03335
OMAiHDYSGWI

Family and domain databases

HAMAPiMF_01672 IolE, 1 hit
InterProiView protein in InterPro
IPR023952 IolE
IPR030823 IolE/MocC
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR04379 myo_inos_iolE, 1 hit

Sequencei

Sequence statusi: Complete.

Q88S37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKAEKDIK WGIAPIGWRN DDIPSIGKDN NLQQLLSDIV VAGFQGTEVG
60 70 80 90 100
GFFPGPEKLN YELKLRNLEI AGQWFSSYII RDGIEKASEA FEKHCQYLKA
110 120 130 140 150
INAPVAVVSE QTYTIQRSDT ANIFKDKPYF TDKEWDEVCK GLNHYGEIAA
160 170 180 190 200
KYGLKVAYHH HMGTGIQTKE ETDRLMANTD PKLVGLLYDT GHIAVSDGDY
210 220 230 240 250
MALLNAHIDR VVHVHFKDVR RSKEEECRAK GLTFQGSFLN GMFTVPGDGD
260 270 280 290 300
LDFKPVYDKL IANNYKGWIV VEAEQDPSKA NPLEMAQIAH RYIKQHLIEN
Length:300
Mass (Da):33,881
Last modified:June 1, 2003 - v1
Checksum:i870B9B88384D024D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA Translation: CCC80568.1
RefSeqiWP_011102249.1, NC_004567.2
YP_004891082.1, NC_004567.2

Genome annotation databases

EnsemblBacteriaiCCC80568; CCC80568; lp_3607
GeneIDi1061765
KEGGilpl:lp_3607
PATRICifig|220668.9.peg.3011

Similar proteinsi

Entry informationi

Entry nameiIOLE_LACPL
AccessioniPrimary (citable) accession number: Q88S37
Secondary accession number(s): F9ULG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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