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Protein

Formyltetrahydrofolate deformylase

Gene

purU-I

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (purU-I), Formyltetrahydrofolate deformylase (purU-III), Formyltetrahydrofolate deformylase (purU-II)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei230UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processOne-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:purU-IImported
Synonyms:purUUniRule annotation
Ordered Locus Names:PP_0327Imported
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)Imported
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_0327.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N0VX-ray2.25A/B/C/D1-285[»]
ProteinModelPortaliQ88R07.
SMRiQ88R07.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ88R07.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 266Formyl_trans_NInterPro annotationAdd BLAST176

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
KOiK01433.
OMAiHADHHTD.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU. 1 hit.
InterProiView protein in InterPro
IPR002376. Formyl_transf_N.
IPR036477. Formyl_transf_N_sf.
IPR004810. PurU.
PANTHERiPTHR42706. PTHR42706. 1 hit.
PfamiView protein in Pfam
PF00551. Formyl_trans_N. 1 hit.
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88R07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAPDTWIL TADCPSMLGT VDVVTRYLFE QRCYVTEHHS FDDRQSGRFF
60 70 80 90 100
IRVEFRQPDD FDEAGFRAGL AERSEAFGMA FELTAPNHRP KVVIMVSKAD
110 120 130 140 150
HCLNDLLYRQ RIGQLGMDVV AVVSNHPDLE PLAHWHKIPY YHFALDPKDK
160 170 180 190 200
PGQERKVLQV IEETGAELVI LARYMQVLSP ELCRRLDGWA INIHHSLLPG
210 220 230 240 250
FKGAKPYHQA YNKGVKMVGA TAHYINNDLD EGPIIAQGVE VVDHSHYPED
260 270 280
LIAKGRDIEC LTLARAVGYH IERRVFLNAN RTVVL
Length:285
Mass (Da):32,442
Last modified:June 1, 2003 - v1
Checksum:i43938565B107F734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN65958.1.
RefSeqiNP_742494.1. NC_002947.4.
WP_003255675.1. NC_002947.4.

Genome annotation databases

EnsemblBacteriaiAAN65958; AAN65958; PP_0327.
GeneIDi1044026.
KEGGippu:PP_0327.
PATRICifig|160488.4.peg.354.

Similar proteinsi

Entry informationi

Entry nameiQ88R07_PSEPK
AccessioniPrimary (citable) accession number: Q88R07
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported