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Q88QS2 (GPH_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoglycolate phosphatase
Short name=PGP
Short name=PGPase
EC=3.1.3.18
Gene names
Ordered Locus Names:PP_0416
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity. HAMAP MF_00495

Catalytic activity

2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495

Pathway

Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. HAMAP MF_00495

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphoglycolate phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Phosphoglycolate phosphatase HAMAP MF_00495
PRO_0000238168

Sites

Active site191Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88QS2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1D91E2F4885ADED9

FASTA27229,604
        10         20         30         40         50         60 
MSGFEQLFPG TLPRLVMFDL DGTLIDSVPD LAAAVDRMLL ELGRPPAGLE AVRHWVGNGA 

        70         80         90        100        110        120 
QVLVRRALAG GIDHADVDDA LAEQALALFM DAYAESHELT VVYPGVRDTL RWLRKQGVEM 

       130        140        150        160        170        180 
ALITNKPERF VGPLLDQMKI GNFFRWIIGG DTLPQKKPDP AALLFVMQMA GVTPQQSLFV 

       190        200        210        220        230        240 
GDSRSDVQAA KAAGVQCVGL TYGYNHGRPI DAESPSLVID DLRALLPGCA DPATGITLAD 

       250        260        270 
LQASQDREST VAVTGKFWMK VIKALARWRW RA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015451 Genomic DNA. Translation: AAN66046.1.
RefSeqNP_742582.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88QS2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ88QS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1044138.
GenomeReviewsGene locus PP_0416 in contig AE015451_GR.
KEGGppu:PP_0416.
NMPDRfig|160488.1.peg.412.
PATRIC19938881. VBIPsePut30601_0448.
TIGRPP_0416.

Phylogenomic databases

eggNOGCOG0546.
HOGENOMHBG742904.
OMAYNYGESI.
PhylomeDBQ88QS2.
ProtClustDBPRK13223.

Enzyme and pathway databases

BioCycPPUT160488:PP_0416-MONOMER.

Family and domain databases

HAMAPMF_00495. GPH_hydrolase_bact.
[Tree]
InterProIPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA_v1.
IPR006402. HAD-SF_hydro_IA_v3.
IPR006549. HAD-SF_hydro_IIIA.
IPR005833. Haloacid_DH/epoxide_hydro.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
Gene3DG3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
G3DSA:1.10.150.240. PGP_dom2. 1 hit.
KOK01091.
PfamPF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00413. HADHALOGNASE.
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01662. HAD-SF-IIIA. 1 hit.
TIGR01449. PGP_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPH_PSEPK
AccessionPrimary (citable) accession number: Q88QS2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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