Reviewed, UniProtKB/Swiss-Prot Q88QQ6 (ARGC1_PSEPK)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase 1
      Short name=AGPR 1
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase 1
      Short name=NAGSA dehydrogenase 1

Gene names

Name:	argC1
Ordered Locus Names:	PP_0432

Organism

Pseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]

Taxonomic identifier

160488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	N-acetyl-gamma-glutamyl-phosphate reductase 1 HAMAP MF_00150		PRO_0000112438
Sites
	Active site	150	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88QQ6-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 6A421D6DEF4ED479	FASTA	344	36,278
	10 20 30 40 50 60 MIKVGIVGGT GYTGVELLRL LAQHPQAEVA VITSRSEAGV AVADMYPNLR GHYDGLAFSV 70 80 90 100 110 120 PDSKALGACD VVFFATPHGV AHALAGELLA AGTKVIDLSA DFRLQDATEW GKWYGQPHGA 130 140 150 160 170 180 PELLKDAVYG LPEVNREKIR QARLIAVPGC YPTATQLGFL PLLEAGLADP SRLIADCKSG 190 200 210 220 230 240 VSGAGRGAAV GSLFCEAGES MKAYAVKGHR HLPEISQGLR LAAGKDIGLT FVPHLTPMIR 250 260 270 280 290 300 GIHATLYANV VDTSVDLQAL FEKRYADEPF VDVMPAGSHP ETRSVRGANV CRIAVHRPQG 310 320 330 340 GDLVVVLSVI DNLVKGASGQ AVQNLNILFG LDERMGLSHA GLLP

References

[1]

"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440." Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O. , Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M. Environ. Microbiol. 4:799-808(2002) [PubMed: 12534463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015451 Genomic DNA. Translation: AAN66062.1.
RefSeq	NP_742598.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1044164.
GenomeReviews	Gene locus PP_0432 in contig AE015451_GR.
KEGG	ppu:PP_0432.
NMPDR	fig|160488.1.peg.428.
TIGR	PP_0432.
Phylogenomic databases
HOGENOM	Q88QQ6.
OMA	Q88QQ6. VCRIAVH.
Enzyme and pathway databases
BioCyc	PPUT160488:PP_0432-MON.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC1_PSEPK

Accession

Primary (citable) accession number: Q88QQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)