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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPPUT160488:G1G01-617-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:PP_0567
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499721 – 637Biosynthetic arginine decarboxylaseAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ88QC7

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_0567

Structurei

3D structure databases

ProteinModelPortaliQ88QC7
SMRiQ88QC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 300Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q88QC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRRTRKDD GSQWTVADSR SVYGIRHWGA GYFAINEAGR VEVRPNGPQS
60 70 80 90 100
APIDLFEQVD ELRQSGLSLP LLVRFPDILQ DRVRQLTGAF DANIARLEYQ
110 120 130 140 150
SQYTALYPIK VNQQEAVVEN IIATQNVSIG LEAGSKPELL AVLALAPKGG
160 170 180 190 200
TIVCNGYKDR EFIRLALMGQ KLGHNVFIVI EKESEVALVI EEAAELKVKP
210 220 230 240 250
QVGLRVRLSS LASSKWADTG GEKSKFGLSA AQLLSVVQRF RDAGLDQGIR
260 270 280 290 300
LLHFHMGSQI ANLADYQHGF KEAIRYYGEL RALGLPVDHI DVGGGLGVDY
310 320 330 340 350
DGTHSRNASS INYDMDDYAG VVVGMLKEFC DAQGLPHPHI FSESGRSLTA
360 370 380 390 400
HHAMLVIQVT DVEKHNDDVP TIENKEALPE TVQWLVDLLG PTDIEMVTET
410 420 430 440 450
YWRATHYMGD VAAQYADGKL SLGEKALAEQ CYFAVCRRLH NSLKARQRSH
460 470 480 490 500
RQVLDELNDK LADKYICNFS VFQSLPDTWA IGQVLPIIPL HRLDEEPMRR
510 520 530 540 550
AVLQDLTCDS DGKINQYVDE QSIETSMPVH AVKEGEDYLL GVFLVGAYQE
560 570 580 590 600
ILGDMHNLFG DTDSVNIYQN ADGSVYHAGI ETHDTIEDML RYVHLSPEEL
610 620 630
MTHYRDKVAS AKITARERTQ YLDALRLGLT RSSYLSS
Length:637
Mass (Da):71,043
Last modified:June 1, 2003 - v1
Checksum:iE59F5EA60F345738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN66194.1
RefSeqiNP_742730.1, NC_002947.4
WP_010951840.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN66194; AAN66194; PP_0567
GeneIDi1044357
KEGGippu:PP_0567
PATRICifig|160488.4.peg.605

Similar proteinsi

Entry informationi

Entry nameiSPEA_PSEPK
AccessioniPrimary (citable) accession number: Q88QC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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