Reviewed, UniProtKB/Swiss-Prot Q88QA3 (ADD_PSEPK)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	PP_0591

Organism

Pseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]

Taxonomic identifier

160488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Adenosine deaminase HAMAP MF_00540		PRO_0000194378
Sites
	Active site	194	1	Potential
	Active site	242	1	Potential
	Active site	275	1	Potential
	Active site	276	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q88QA3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 78D54FA84F9E93D5	FASTA	315	35,846
	10 20 30 40 50 60 MYDWLNALPK AELHLHLEGS LEPELLFALA ERNKIALPWA DVETLRGAYA FNNLQEFLDL 70 80 90 100 110 120 YYQGADVLRT EQDFYDLTWA YLQRCKAQNV IHTEPFFDPQ THTDRGIAFE VVLNGISQAL 130 140 150 160 170 180 KDGREQLGIS SGLILSFLRH LSEDEAQKTL DQALPFRDAF IAVGLDSSEM GHPPSKFQRV 190 200 210 220 230 240 FDRARSEGFV AVAHAGEEGP PEYIWEALDL LKIKRIDHGV RAIEDERLMQ RIIDEQIPLT 250 260 270 280 290 300 VCPLSNTKLC VFDHMSQHNI LDMLERGVKV TVNSDDPAYF GGYVTENFHA LHTHLGMTED 310 QARRLAQNSL DARLV

References

[1]

"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440." Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O. , Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M. Environ. Microbiol. 4:799-808(2002) [PubMed: 12534463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015451 Genomic DNA. Translation: AAN66218.1.
RefSeq	NP_742754.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1044402.
GenomeReviews	Gene locus PP_0591 in contig AE015451_GR.
KEGG	ppu:PP_0591.
NMPDR	fig|160488.1.peg.584.
TIGR	PP_0591.
Phylogenomic databases
HOGENOM	Q88QA3.
OMA	Q88QA3. LAQNSLD.
Enzyme and pathway databases
BioCyc	PPUT160488:PP_0591-MON.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_PSEPK

Accession

Primary (citable) accession number: Q88QA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)