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Protein

Probable malate dehydrogenase

Gene

mdh

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51SubstrateBy similarity1
Binding sitei57SubstrateBy similarity1
Binding sitei64NADBy similarity1
Binding sitei89SubstrateBy similarity1
Binding sitei120SubstrateBy similarity1
Active sitei144Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi87 – 89NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenaseCurated (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:PP_0654
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134601 – 278Probable malate dehydrogenaseAdd BLAST278

Proteomic databases

PRIDEiQ88Q44

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_0654

Structurei

3D structure databases

ProteinModelPortaliQ88Q44
SMRiQ88Q44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiQCTPKVE

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

Q88Q44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVQGELAQG KALDVWQAAV DSGSDTHVHG GAKAEMLEGS ELVVITAGVP
60 70 80 90 100
RKPGQSRQDV LSTNLPILDS IMADIKHHAP TATVLVVSNP VDVLTYRAWS
110 120 130 140 150
VSGQGRDKVF GQAGVLDTAR MKCFIAEQTG FSARDITALV LGGHGDSMVP
160 170 180 190 200
LMRYCQIGSV PLSHFLSSEQ IEQIVERTRK GGGEILGLKK TGSACDAPGV
210 220 230 240 250
AIAQMVDAIA NGRNRILPAV AILEGEYGRT DIAMGVPCVL AEKGLARIIE
260 270
LPLDAQEQAM FDHSADQVAR DIAEMKAL
Length:278
Mass (Da):29,434
Last modified:June 1, 2003 - v1
Checksum:i9F48BC27CC4D54C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN66279.1
RefSeqiNP_742815.2, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN66279; AAN66279; PP_0654
GeneIDi1044477
KEGGippu:PP_0654
PATRICifig|160488.4.peg.699

Similar proteinsi

Entry informationi

Entry nameiMDH_PSEPK
AccessioniPrimary (citable) accession number: Q88Q44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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