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Q88Q44

- MDH_PSEPK

UniProt

Q88Q44 - MDH_PSEPK

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Protein

Probable malate dehydrogenase

Gene
mdh, PP_0654
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511Substrate By similarity
Binding sitei57 – 571Substrate By similarity
Binding sitei64 – 641NAD By similarity
Binding sitei89 – 891Substrate By similarity
Binding sitei120 – 1201Substrate By similarity
Active sitei144 – 1441Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 893NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-683-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:PP_0654
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Probable malate dehydrogenasePRO_0000113460Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_0654.

Structurei

3D structure databases

ProteinModelPortaliQ88Q44.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiKTYAKDA.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88Q44-1 [UniParc]FASTAAdd to Basket

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MDVQGELAQG KALDVWQAAV DSGSDTHVHG GAKAEMLEGS ELVVITAGVP    50
RKPGQSRQDV LSTNLPILDS IMADIKHHAP TATVLVVSNP VDVLTYRAWS 100
VSGQGRDKVF GQAGVLDTAR MKCFIAEQTG FSARDITALV LGGHGDSMVP 150
LMRYCQIGSV PLSHFLSSEQ IEQIVERTRK GGGEILGLKK TGSACDAPGV 200
AIAQMVDAIA NGRNRILPAV AILEGEYGRT DIAMGVPCVL AEKGLARIIE 250
LPLDAQEQAM FDHSADQVAR DIAEMKAL 278
Length:278
Mass (Da):29,434
Last modified:June 1, 2003 - v1
Checksum:i9F48BC27CC4D54C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66279.1.
RefSeqiNP_742815.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN66279; AAN66279; PP_0654.
GeneIDi1044477.
KEGGippu:PP_0654.
PATRICi19939419. VBIPsePut30601_0699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66279.1 .
RefSeqi NP_742815.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88Q44.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_0654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN66279 ; AAN66279 ; PP_0654 .
GeneIDi 1044477.
KEGGi ppu:PP_0654.
PATRICi 19939419. VBIPsePut30601_0699.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi KTYAKDA.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci PPUT160488:GIXO-683-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiMDH_PSEPK
AccessioniPrimary (citable) accession number: Q88Q44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi