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Q88Q44

- MDH_PSEPK

UniProt

Q88Q44 - MDH_PSEPK

Protein

Probable malate dehydrogenase

Gene

mdh

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511SubstrateBy similarity
    Binding sitei57 – 571SubstrateBy similarity
    Binding sitei64 – 641NADBy similarity
    Binding sitei89 – 891SubstrateBy similarity
    Binding sitei120 – 1201SubstrateBy similarity
    Active sitei144 – 1441Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi87 – 893NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-683-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    Ordered Locus Names:PP_0654
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Probable malate dehydrogenasePRO_0000113460Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160488.PP_0654.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88Q44.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiKTYAKDA.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88Q44-1 [UniParc]FASTAAdd to Basket

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    MDVQGELAQG KALDVWQAAV DSGSDTHVHG GAKAEMLEGS ELVVITAGVP    50
    RKPGQSRQDV LSTNLPILDS IMADIKHHAP TATVLVVSNP VDVLTYRAWS 100
    VSGQGRDKVF GQAGVLDTAR MKCFIAEQTG FSARDITALV LGGHGDSMVP 150
    LMRYCQIGSV PLSHFLSSEQ IEQIVERTRK GGGEILGLKK TGSACDAPGV 200
    AIAQMVDAIA NGRNRILPAV AILEGEYGRT DIAMGVPCVL AEKGLARIIE 250
    LPLDAQEQAM FDHSADQVAR DIAEMKAL 278
    Length:278
    Mass (Da):29,434
    Last modified:June 1, 2003 - v1
    Checksum:i9F48BC27CC4D54C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66279.1.
    RefSeqiNP_742815.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN66279; AAN66279; PP_0654.
    GeneIDi1044477.
    KEGGippu:PP_0654.
    PATRICi19939419. VBIPsePut30601_0699.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66279.1 .
    RefSeqi NP_742815.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88Q44.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_0654.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN66279 ; AAN66279 ; PP_0654 .
    GeneIDi 1044477.
    KEGGi ppu:PP_0654.
    PATRICi 19939419. VBIPsePut30601_0699.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi KTYAKDA.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci PPUT160488:GIXO-683-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiMDH_PSEPK
    AccessioniPrimary (citable) accession number: Q88Q44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3