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Q88Q44 (MDH_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:PP_0654
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Probable malate dehydrogenase
PRO_0000113460

Regions

Nucleotide binding87 – 893NAD By similarity

Sites

Active site1441Proton acceptor By similarity
Binding site511Substrate By similarity
Binding site571Substrate By similarity
Binding site641NAD By similarity
Binding site891Substrate By similarity
Binding site1201Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88Q44 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 9F48BC27CC4D54C5

FASTA27829,434
        10         20         30         40         50         60 
MDVQGELAQG KALDVWQAAV DSGSDTHVHG GAKAEMLEGS ELVVITAGVP RKPGQSRQDV 

        70         80         90        100        110        120 
LSTNLPILDS IMADIKHHAP TATVLVVSNP VDVLTYRAWS VSGQGRDKVF GQAGVLDTAR 

       130        140        150        160        170        180 
MKCFIAEQTG FSARDITALV LGGHGDSMVP LMRYCQIGSV PLSHFLSSEQ IEQIVERTRK 

       190        200        210        220        230        240 
GGGEILGLKK TGSACDAPGV AIAQMVDAIA NGRNRILPAV AILEGEYGRT DIAMGVPCVL 

       250        260        270 
AEKGLARIIE LPLDAQEQAM FDHSADQVAR DIAEMKAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015451 Genomic DNA. Translation: AAN66279.1.
RefSeqNP_742815.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88Q44.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160488.PP_0654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN66279; AAN66279; PP_0654.
GeneID1044477.
KEGGppu:PP_0654.
PATRIC19939419. VBIPsePut30601_0699.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAKTYAKDA.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycPPUT160488:GIXO-683-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_PSEPK
AccessionPrimary (citable) accession number: Q88Q44
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families