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Q88P65

- GCSP1_PSEPK

UniProt

Q88P65 - GCSP1_PSEPK

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Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).By similarity

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-1020-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene namesi
Name:gcvP1
Synonyms:gcvP-1
Ordered Locus Names:PP_0988
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 951951Glycine dehydrogenase (decarboxylating) 1PRO_0000166927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

STRINGi160488.PP_0988.

Structurei

3D structure databases

ProteinModelPortaliQ88P65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88P65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTINLGTANE FIARHIGPRA ADEQAMLTAL GFDSLDAMTA AVIPDSIKGT
60 70 80 90 100
SVLGSHDGQS EADALAALKA IAGKNQLFKS YIGQGYYNTH TPAPILRNLL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLTGLPIA NASLLDEATA
160 170 180 190 200
AAEAMTFCKR LSKNKSSHAF FASVHCHPQT LDVLRTRAEP LGIEVVVGDE
210 220 230 240 250
RELGDVSAFF GALLQYPASN GEVFDYREVV QRFHAANALV AVAADLLALT
260 270 280 290 300
LLTPPGEFDA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG
310 320 330 340 350
VSIDRFGKTA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMFAVYHG
360 370 380 390 400
PAGLKRIAER THALTAILAA GLKALGVQVV GASAFDTLTL ATGTATASLH
410 420 430 440 450
DKARAQGINL RQIDAAHVGL SLDETSTQAD VESLWQLLGG EQAQPDFTAL
460 470 480 490 500
AASTGSLLPA ALLRQSAILE HPVFNRYHSE TELMRYLRRL ADKDLALDRS
510 520 530 540 550
MIPLGSCTMK LNAASEMIPV TWAEFGNLHP FAPAEQSQGY LQMTTELEAM
560 570 580 590 600
LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHRSRGEGHR DICLIPSSAH
610 620 630 640 650
GTNPATAHMA GMRVVVTACD ARGNVDVEDL RAKAIEHRER LAAIMITYPS
660 670 680 690 700
THGVFEEAIG EICAIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGVGPIG VKSHLAPFLP GHAQLENTQG AVCAAPFGSA
760 770 780 790 800
SILPITWMYI RMMGGAGLKR ASQMAILNAN YIARRLEEHY PVLYTGGNGL
810 820 830 840 850
VAHECILDLR PLKDTSGISV DDVAKRLIDF GFHAPTMSFP VAGTLMIEPT
860 870 880 890 900
ESESKEELDR FCNAMIQIRE EIRAVEDGSL DKDDNPLKNA PHTAAELVGE
910 920 930 940 950
WTHGYSREQA VYPLASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD

A
Length:951
Mass (Da):101,992
Last modified:June 1, 2003 - v1
Checksum:iEDDBDB715CDE148E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66613.1.
RefSeqiNP_743149.1. NC_002947.3.
WP_003255089.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN66613; AAN66613; PP_0988.
GeneIDi1044914.
KEGGippu:PP_0988.
PATRICi19940124. VBIPsePut30601_1048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66613.1 .
RefSeqi NP_743149.1. NC_002947.3.
WP_003255089.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88P65.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_0988.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN66613 ; AAN66613 ; PP_0988 .
GeneIDi 1044914.
KEGGi ppu:PP_0988.
PATRICi 19940124. VBIPsePut30601_1048.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PPUT160488:GIXO-1020-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiGCSP1_PSEPK
AccessioniPrimary (citable) accession number: Q88P65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3