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Q88P65 (GCSP1_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene names
Name:gcvP1
Synonyms:gcvP-1
Ordered Locus Names:PP_0988
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length951 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 951951Glycine dehydrogenase (decarboxylating) 1 HAMAP-Rule MF_00711
PRO_0000166927

Amino acid modifications

Modified residue7031N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88P65 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: EDDBDB715CDE148E

FASTA951101,992
        10         20         30         40         50         60 
MTINLGTANE FIARHIGPRA ADEQAMLTAL GFDSLDAMTA AVIPDSIKGT SVLGSHDGQS 

        70         80         90        100        110        120 
EADALAALKA IAGKNQLFKS YIGQGYYNTH TPAPILRNLL ENPAWYTAYT PYQPEISQGR 

       130        140        150        160        170        180 
LEALLNFQTL ISDLTGLPIA NASLLDEATA AAEAMTFCKR LSKNKSSHAF FASVHCHPQT 

       190        200        210        220        230        240 
LDVLRTRAEP LGIEVVVGDE RELGDVSAFF GALLQYPASN GEVFDYREVV QRFHAANALV 

       250        260        270        280        290        300 
AVAADLLALT LLTPPGEFDA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG 

       310        320        330        340        350        360 
VSIDRFGKTA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMFAVYHG PAGLKRIAER 

       370        380        390        400        410        420 
THALTAILAA GLKALGVQVV GASAFDTLTL ATGTATASLH DKARAQGINL RQIDAAHVGL 

       430        440        450        460        470        480 
SLDETSTQAD VESLWQLLGG EQAQPDFTAL AASTGSLLPA ALLRQSAILE HPVFNRYHSE 

       490        500        510        520        530        540 
TELMRYLRRL ADKDLALDRS MIPLGSCTMK LNAASEMIPV TWAEFGNLHP FAPAEQSQGY 

       550        560        570        580        590        600 
LQMTTELEAM LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHRSRGEGHR DICLIPSSAH 

       610        620        630        640        650        660 
GTNPATAHMA GMRVVVTACD ARGNVDVEDL RAKAIEHRER LAAIMITYPS THGVFEEAIG 

       670        680        690        700        710        720 
EICAIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN LHKTFCIPHG GGGPGVGPIG 

       730        740        750        760        770        780 
VKSHLAPFLP GHAQLENTQG AVCAAPFGSA SILPITWMYI RMMGGAGLKR ASQMAILNAN 

       790        800        810        820        830        840 
YIARRLEEHY PVLYTGGNGL VAHECILDLR PLKDTSGISV DDVAKRLIDF GFHAPTMSFP 

       850        860        870        880        890        900 
VAGTLMIEPT ESESKEELDR FCNAMIQIRE EIRAVEDGSL DKDDNPLKNA PHTAAELVGE 

       910        920        930        940        950 
WTHGYSREQA VYPLASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD A 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015451 Genomic DNA. Translation: AAN66613.1.
RefSeqNP_743149.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88P65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160488.PP_0988.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN66613; AAN66613; PP_0988.
GeneID1044914.
KEGGppu:PP_0988.
PATRIC19940124. VBIPsePut30601_1048.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAAELMPVS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPPUT160488:GIXO-1020-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP1_PSEPK
AccessionPrimary (citable) accession number: Q88P65
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families