Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q88P65

- GCSP1_PSEPK

UniProt

Q88P65 - GCSP1_PSEPK

Protein

Glycine dehydrogenase (decarboxylating) 1

Gene

gcvP1

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.By similarity

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-1020-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) 1 (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P-protein 1
    Glycine decarboxylase 1
    Glycine dehydrogenase (aminomethyl-transferring) 1
    Gene namesi
    Name:gcvP1
    Synonyms:gcvP-1
    Ordered Locus Names:PP_0988
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 951951Glycine dehydrogenase (decarboxylating) 1PRO_0000166927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

    Protein-protein interaction databases

    STRINGi160488.PP_0988.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88P65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88P65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTINLGTANE FIARHIGPRA ADEQAMLTAL GFDSLDAMTA AVIPDSIKGT    50
    SVLGSHDGQS EADALAALKA IAGKNQLFKS YIGQGYYNTH TPAPILRNLL 100
    ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLTGLPIA NASLLDEATA 150
    AAEAMTFCKR LSKNKSSHAF FASVHCHPQT LDVLRTRAEP LGIEVVVGDE 200
    RELGDVSAFF GALLQYPASN GEVFDYREVV QRFHAANALV AVAADLLALT 250
    LLTPPGEFDA DVAIGSAQRF GVPLGFGGPH AAYFATRDAF KRDMPGRLVG 300
    VSIDRFGKTA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMFAVYHG 350
    PAGLKRIAER THALTAILAA GLKALGVQVV GASAFDTLTL ATGTATASLH 400
    DKARAQGINL RQIDAAHVGL SLDETSTQAD VESLWQLLGG EQAQPDFTAL 450
    AASTGSLLPA ALLRQSAILE HPVFNRYHSE TELMRYLRRL ADKDLALDRS 500
    MIPLGSCTMK LNAASEMIPV TWAEFGNLHP FAPAEQSQGY LQMTTELEAM 550
    LCAATGYDAV SLQPNAGSQG EYAGLLAIRA YHRSRGEGHR DICLIPSSAH 600
    GTNPATAHMA GMRVVVTACD ARGNVDVEDL RAKAIEHRER LAAIMITYPS 650
    THGVFEEAIG EICAIIHDNG GQVYIDGANM NAMVGLCAPG KFGGDVSHLN 700
    LHKTFCIPHG GGGPGVGPIG VKSHLAPFLP GHAQLENTQG AVCAAPFGSA 750
    SILPITWMYI RMMGGAGLKR ASQMAILNAN YIARRLEEHY PVLYTGGNGL 800
    VAHECILDLR PLKDTSGISV DDVAKRLIDF GFHAPTMSFP VAGTLMIEPT 850
    ESESKEELDR FCNAMIQIRE EIRAVEDGSL DKDDNPLKNA PHTAAELVGE 900
    WTHGYSREQA VYPLASLVEG KYWPPVGRVD NVFGDRNLVC ACPSIESYQD 950
    A 951
    Length:951
    Mass (Da):101,992
    Last modified:June 1, 2003 - v1
    Checksum:iEDDBDB715CDE148E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66613.1.
    RefSeqiNP_743149.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN66613; AAN66613; PP_0988.
    GeneIDi1044914.
    KEGGippu:PP_0988.
    PATRICi19940124. VBIPsePut30601_1048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66613.1 .
    RefSeqi NP_743149.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88P65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_0988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN66613 ; AAN66613 ; PP_0988 .
    GeneIDi 1044914.
    KEGGi ppu:PP_0988.
    PATRICi 19940124. VBIPsePut30601_1048.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PPUT160488:GIXO-1020-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiGCSP1_PSEPK
    AccessioniPrimary (citable) accession number: Q88P65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3