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Q88ND5 (ALGA_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alginate biosynthesis protein AlgA

Including the following 2 domains:

  1. Mannose-6-phosphate isomerase
    EC=5.3.1.8
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name=PMI
  2. Mannose-1-phosphate guanylyltransferase
    EC=2.7.7.13
    Alternative name(s):
    GDP-mannose pyrophosphorylase
    Short name=GMP
    Short name=GMPP
    GTP--mannose-1-phosphate guanylyltransferase
Gene names
Name:algA
Ordered Locus Names:PP_1277
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics By similarity.

Catalytic activity

D-mannose 6-phosphate = D-fructose 6-phosphate.

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Cofactor

Cobalt (for PMI) By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Alginate biosynthesis protein AlgA
PRO_0000194250

Sequences

Sequence LengthMass (Da)Tools
Q88ND5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 81668C8ED0E2A90C

FASTA48553,896
        10         20         30         40         50         60 
MMIPVILSGG SGSRLWPLSR KQFPKQFLAL TGEHTLFQQT IERLVFEGMD TPIVVCNKDH 

        70         80         90        100        110        120 
KFIVQEQLAA LKLETQGILM EPFGRNTAPA VAMAAMKLVN EGRDELMLVL PADHVIDDQK 

       130        140        150        160        170        180 
ALQRALALAT VAAERGEMVL FGVPATKPET GYGYIRSSQD ALLPEGVARV AQFVEKPDEK 

       190        200        210        220        230        240 
RAAEFVQAGG YFWNSGMFLF RASRFLEELK KHDGDIYDTC VLALERSQED GDVLSIDEAT 

       250        260        270        280        290        300 
FACCPDNSID YAVMEKTQRA CVVPMSAGWS DVGCWSSLWE VHEKDDNGNV TKGDVVVQDS 

       310        320        330        340        350        360 
RNCMIHGNGK LVSVIGLENI VVVETKDAMM IAHKDKVQGV KQMVKTLDEQ GRTETQNHLE 

       370        380        390        400        410        420 
VYRPWGSYDS VDMGGRFQVK HITVKPGASL SLQMHHHRAE HWIVVSGTAE VTCDENVFLL 

       430        440        450        460        470        480 
TENQSTYIPI ASVHRLRNPG KIPLEIIEVQ SGSYLGEDDI ERFEDVYGRT STPIERGVSV 


KTIAQ 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015451 Genomic DNA. Translation: AAN66901.1.
RefSeqNP_743437.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88ND5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160488.PP_1277.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN66901; AAN66901; PP_1277.
GeneID1043792.
KEGGppu:PP_1277.
PATRIC19940751. VBIPsePut30601_1354.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0662.
HOGENOMHOG000153549.
KOK16011.
OMAEPSIYEN.
OrthoDBEOG6X3W6T.
ProtClustDBCLSK868066.

Enzyme and pathway databases

BioCycPPUT160488:GIXO-1317-MONOMER.
UniPathwayUPA00126; UER00423.
UPA00126; UER00930.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR006375. Man1P_GuaTrfase/Man6P_Isoase.
IPR001538. Man6P_isomerase-2_C.
IPR005835. NTP_transferase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamPF01050. MannoseP_isomer. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01479. GMP_PMI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALGA_PSEPK
AccessionPrimary (citable) accession number: Q88ND5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: November 13, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways