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Q88ND5

- ALGA_PSEPK

UniProt

Q88ND5 - ALGA_PSEPK

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Protein
Alginate biosynthesis protein AlgA
Gene
algA, PP_1277
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics By similarity.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Cofactori

Cobalt (for PMI) By similarity.

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. mannose-1-phosphate guanylyltransferase activity Source: UniProtKB-EC
  3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. alginic acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

Alginate biosynthesis

Keywords - Ligandi

Cobalt, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-1317-MONOMER.
UniPathwayiUPA00126; UER00423.
UPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Alginate biosynthesis protein AlgA
Including the following 2 domains:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Mannose-1-phosphate guanylyltransferase (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase
Short name:
GMP
Short name:
GMPP
GTP--mannose-1-phosphate guanylyltransferase
Gene namesi
Name:algA
Ordered Locus Names:PP_1277
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Alginate biosynthesis protein AlgA
PRO_0000194250Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi160488.PP_1277.

Structurei

3D structure databases

ProteinModelPortaliQ88ND5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0662.
HOGENOMiHOG000153549.
KOiK16011.
OMAiELKKHDP.
OrthoDBiEOG6X3W6T.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
3.90.550.10. 1 hit.
InterProiIPR006375. Man1P_GuaTrfase/Man6P_Isoase.
IPR001538. Man6P_isomerase-2_C.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF01050. MannoseP_isomer. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
SSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01479. GMP_PMI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88ND5-1 [UniParc]FASTAAdd to Basket

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MMIPVILSGG SGSRLWPLSR KQFPKQFLAL TGEHTLFQQT IERLVFEGMD    50
TPIVVCNKDH KFIVQEQLAA LKLETQGILM EPFGRNTAPA VAMAAMKLVN 100
EGRDELMLVL PADHVIDDQK ALQRALALAT VAAERGEMVL FGVPATKPET 150
GYGYIRSSQD ALLPEGVARV AQFVEKPDEK RAAEFVQAGG YFWNSGMFLF 200
RASRFLEELK KHDGDIYDTC VLALERSQED GDVLSIDEAT FACCPDNSID 250
YAVMEKTQRA CVVPMSAGWS DVGCWSSLWE VHEKDDNGNV TKGDVVVQDS 300
RNCMIHGNGK LVSVIGLENI VVVETKDAMM IAHKDKVQGV KQMVKTLDEQ 350
GRTETQNHLE VYRPWGSYDS VDMGGRFQVK HITVKPGASL SLQMHHHRAE 400
HWIVVSGTAE VTCDENVFLL TENQSTYIPI ASVHRLRNPG KIPLEIIEVQ 450
SGSYLGEDDI ERFEDVYGRT STPIERGVSV KTIAQ 485
Length:485
Mass (Da):53,896
Last modified:June 1, 2003 - v1
Checksum:i81668C8ED0E2A90C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66901.1.
RefSeqiNP_743437.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN66901; AAN66901; PP_1277.
GeneIDi1043792.
KEGGippu:PP_1277.
PATRICi19940751. VBIPsePut30601_1354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66901.1 .
RefSeqi NP_743437.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88ND5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_1277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN66901 ; AAN66901 ; PP_1277 .
GeneIDi 1043792.
KEGGi ppu:PP_1277.
PATRICi 19940751. VBIPsePut30601_1354.

Phylogenomic databases

eggNOGi COG0662.
HOGENOMi HOG000153549.
KOi K16011.
OMAi ELKKHDP.
OrthoDBi EOG6X3W6T.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .
UPA00126 ; UER00930 .
BioCyci PPUT160488:GIXO-1317-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
3.90.550.10. 1 hit.
InterProi IPR006375. Man1P_GuaTrfase/Man6P_Isoase.
IPR001538. Man6P_isomerase-2_C.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF01050. MannoseP_isomer. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01479. GMP_PMI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiALGA_PSEPK
AccessioniPrimary (citable) accession number: Q88ND5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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