Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q88ND5

- ALGA_PSEPK

UniProt

Q88ND5 - ALGA_PSEPK

Protein

Alginate biosynthesis protein AlgA

Gene

algA

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics By similarity.By similarity

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.
    GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

    Cofactori

    Cobalt (for PMI).By similarity

    Pathwayi

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. mannose-1-phosphate guanylyltransferase activity Source: UniProtKB-EC
    3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. alginic acid biosynthetic process Source: UniProtKB-KW
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Alginate biosynthesis

    Keywords - Ligandi

    Cobalt, GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-1317-MONOMER.
    UniPathwayiUPA00126; UER00423.
    UPA00126; UER00930.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alginate biosynthesis protein AlgA
    Including the following 2 domains:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Mannose-1-phosphate guanylyltransferase (EC:2.7.7.13)
    Alternative name(s):
    GDP-mannose pyrophosphorylase
    Short name:
    GMP
    Short name:
    GMPP
    GTP--mannose-1-phosphate guanylyltransferase
    Gene namesi
    Name:algA
    Ordered Locus Names:PP_1277
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Alginate biosynthesis protein AlgAPRO_0000194250Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi160488.PP_1277.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88ND5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0662.
    HOGENOMiHOG000153549.
    KOiK16011.
    OMAiELKKHDP.
    OrthoDBiEOG6X3W6T.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    3.90.550.10. 1 hit.
    InterProiIPR006375. Man1P_GuaTrfase/Man6P_Isoase.
    IPR001538. Man6P_isomerase-2_C.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF01050. MannoseP_isomer. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    SSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01479. GMP_PMI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88ND5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMIPVILSGG SGSRLWPLSR KQFPKQFLAL TGEHTLFQQT IERLVFEGMD    50
    TPIVVCNKDH KFIVQEQLAA LKLETQGILM EPFGRNTAPA VAMAAMKLVN 100
    EGRDELMLVL PADHVIDDQK ALQRALALAT VAAERGEMVL FGVPATKPET 150
    GYGYIRSSQD ALLPEGVARV AQFVEKPDEK RAAEFVQAGG YFWNSGMFLF 200
    RASRFLEELK KHDGDIYDTC VLALERSQED GDVLSIDEAT FACCPDNSID 250
    YAVMEKTQRA CVVPMSAGWS DVGCWSSLWE VHEKDDNGNV TKGDVVVQDS 300
    RNCMIHGNGK LVSVIGLENI VVVETKDAMM IAHKDKVQGV KQMVKTLDEQ 350
    GRTETQNHLE VYRPWGSYDS VDMGGRFQVK HITVKPGASL SLQMHHHRAE 400
    HWIVVSGTAE VTCDENVFLL TENQSTYIPI ASVHRLRNPG KIPLEIIEVQ 450
    SGSYLGEDDI ERFEDVYGRT STPIERGVSV KTIAQ 485
    Length:485
    Mass (Da):53,896
    Last modified:June 1, 2003 - v1
    Checksum:i81668C8ED0E2A90C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66901.1.
    RefSeqiNP_743437.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN66901; AAN66901; PP_1277.
    GeneIDi1043792.
    KEGGippu:PP_1277.
    PATRICi19940751. VBIPsePut30601_1354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66901.1 .
    RefSeqi NP_743437.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88ND5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_1277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN66901 ; AAN66901 ; PP_1277 .
    GeneIDi 1043792.
    KEGGi ppu:PP_1277.
    PATRICi 19940751. VBIPsePut30601_1354.

    Phylogenomic databases

    eggNOGi COG0662.
    HOGENOMi HOG000153549.
    KOi K16011.
    OMAi ELKKHDP.
    OrthoDBi EOG6X3W6T.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00423 .
    UPA00126 ; UER00930 .
    BioCyci PPUT160488:GIXO-1317-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    3.90.550.10. 1 hit.
    InterProi IPR006375. Man1P_GuaTrfase/Man6P_Isoase.
    IPR001538. Man6P_isomerase-2_C.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF01050. MannoseP_isomer. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01479. GMP_PMI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiALGA_PSEPK
    AccessioniPrimary (citable) accession number: Q88ND5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3