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Q88NC4

- ALGD_PSEPK

UniProt

Q88NC4 - ALGD_PSEPK

Protein

GDP-mannose 6-dehydrogenase

Gene

algD

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics By similarity.By similarity

    Catalytic activityi

    GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei10 – 101NAD bindingBy similarity
    Sitei11 – 111NAD bindingBy similarity
    Sitei30 – 301NAD bindingBy similarity
    Sitei35 – 351NAD bindingBy similarity
    Sitei86 – 861NAD bindingBy similarity
    Sitei161 – 1611NAD bindingBy similarity
    Active sitei268 – 2681By similarity
    Sitei271 – 2711NAD bindingBy similarity
    Sitei331 – 3311NAD bindingBy similarity

    GO - Molecular functioni

    1. GDP-mannose 6-dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. alginic acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Alginate biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-1328-MONOMER.
    UniPathwayiUPA00286.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-mannose 6-dehydrogenase (EC:1.1.1.132)
    Short name:
    GMD
    Gene namesi
    Name:algD
    Ordered Locus Names:PP_1288
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438GDP-mannose 6-dehydrogenasePRO_0000074068Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160488.PP_1288.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88NC4.
    SMRiQ88NC4. Positions 1-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1004.
    HOGENOMiHOG000153773.
    KOiK00066.
    OMAiGDLELDY.
    OrthoDBiEOG6ZSP7N.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR028358. GDPman_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500135. GDPman_DH. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88NC4-1 [UniParc]FASTAAdd to Basket

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    MRISIFGLGY VGAVCAGCLT ARGHEVIGVD VSSTKIDLIN QGKSPIVEPG    50
    LEALLQQGIA NGRLRGTTDF AEAIRASDVS MICVGTPSKK NGDLGLEYIE 100
    SVCREIGYVL RDTTRRHTIV VRSTVLPGTV KNVVIPILED CSGKKAGVDF 150
    GVAVNPEFLR ESTAIKDYDQ PPMTVIGELD SASGDILQAL YEELDAPIIR 200
    KPIEVAEMIK YTCNVWHATK VTFANEIGNI AKAVGVDGRE VMDVVCQDKV 250
    LNLSQYYMRP GFAFGGSCLP KDVRALTYRA ASLDVRAPLL DSLMRSNESQ 300
    VQNAFELIEA HDKRKVALLG LSFKAGTDDL RESPLVELAE RLIGKGYQLD 350
    IYDENVQYAR VHGANKDYIE SKIPHVSSLL NANLQQVIDN ADIIVLGNRD 400
    EQFRALALQA PAGKQVIDLV GFMNKPTSTT ARTEGICW 438
    Length:438
    Mass (Da):47,728
    Last modified:June 1, 2003 - v1
    Checksum:i51CEBCDBEE95B748
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66912.1.
    RefSeqiNP_743448.1. NC_002947.3.
    WP_010952417.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN66912; AAN66912; PP_1288.
    GeneIDi1041882.
    KEGGippu:PP_1288.
    PATRICi19940773. VBIPsePut30601_1365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN66912.1 .
    RefSeqi NP_743448.1. NC_002947.3.
    WP_010952417.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88NC4.
    SMRi Q88NC4. Positions 1-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_1288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN66912 ; AAN66912 ; PP_1288 .
    GeneIDi 1041882.
    KEGGi ppu:PP_1288.
    PATRICi 19940773. VBIPsePut30601_1365.

    Phylogenomic databases

    eggNOGi COG1004.
    HOGENOMi HOG000153773.
    KOi K00066.
    OMAi GDLELDY.
    OrthoDBi EOG6ZSP7N.

    Enzyme and pathway databases

    UniPathwayi UPA00286 .
    BioCyci PPUT160488:GIXO-1328-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR028358. GDPman_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500135. GDPman_DH. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiALGD_PSEPK
    AccessioniPrimary (citable) accession number: Q88NC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3