SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q88NC4

- ALGD_PSEPK

UniProt

Q88NC4 - ALGD_PSEPK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
GDP-mannose 6-dehydrogenase
Gene
algD, PP_1288
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics By similarity.

Catalytic activityi

GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei10 – 101NAD binding By similarity
Sitei11 – 111NAD binding By similarity
Sitei30 – 301NAD binding By similarity
Sitei35 – 351NAD binding By similarity
Sitei86 – 861NAD binding By similarity
Sitei161 – 1611NAD binding By similarity
Active sitei268 – 2681 By similarity
Sitei271 – 2711NAD binding By similarity
Sitei331 – 3311NAD binding By similarity

GO - Molecular functioni

  1. GDP-mannose 6-dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. alginic acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Alginate biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-1328-MONOMER.
UniPathwayiUPA00286.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-mannose 6-dehydrogenase (EC:1.1.1.132)
Short name:
GMD
Gene namesi
Name:algD
Ordered Locus Names:PP_1288
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438GDP-mannose 6-dehydrogenase
PRO_0000074068Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_1288.

Structurei

3D structure databases

ProteinModelPortaliQ88NC4.
SMRiQ88NC4. Positions 1-438.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000153773.
KOiK00066.
OMAiGDLELDY.
OrthoDBiEOG6ZSP7N.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR028358. GDPman_DH.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500135. GDPman_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88NC4-1 [UniParc]FASTAAdd to Basket

« Hide

MRISIFGLGY VGAVCAGCLT ARGHEVIGVD VSSTKIDLIN QGKSPIVEPG    50
LEALLQQGIA NGRLRGTTDF AEAIRASDVS MICVGTPSKK NGDLGLEYIE 100
SVCREIGYVL RDTTRRHTIV VRSTVLPGTV KNVVIPILED CSGKKAGVDF 150
GVAVNPEFLR ESTAIKDYDQ PPMTVIGELD SASGDILQAL YEELDAPIIR 200
KPIEVAEMIK YTCNVWHATK VTFANEIGNI AKAVGVDGRE VMDVVCQDKV 250
LNLSQYYMRP GFAFGGSCLP KDVRALTYRA ASLDVRAPLL DSLMRSNESQ 300
VQNAFELIEA HDKRKVALLG LSFKAGTDDL RESPLVELAE RLIGKGYQLD 350
IYDENVQYAR VHGANKDYIE SKIPHVSSLL NANLQQVIDN ADIIVLGNRD 400
EQFRALALQA PAGKQVIDLV GFMNKPTSTT ARTEGICW 438
Length:438
Mass (Da):47,728
Last modified:June 1, 2003 - v1
Checksum:i51CEBCDBEE95B748
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66912.1.
RefSeqiNP_743448.1. NC_002947.3.
WP_010952417.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN66912; AAN66912; PP_1288.
GeneIDi1041882.
KEGGippu:PP_1288.
PATRICi19940773. VBIPsePut30601_1365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN66912.1 .
RefSeqi NP_743448.1. NC_002947.3.
WP_010952417.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88NC4.
SMRi Q88NC4. Positions 1-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_1288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN66912 ; AAN66912 ; PP_1288 .
GeneIDi 1041882.
KEGGi ppu:PP_1288.
PATRICi 19940773. VBIPsePut30601_1365.

Phylogenomic databases

eggNOGi COG1004.
HOGENOMi HOG000153773.
KOi K00066.
OMAi GDLELDY.
OrthoDBi EOG6ZSP7N.

Enzyme and pathway databases

UniPathwayi UPA00286 .
BioCyci PPUT160488:GIXO-1328-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR028358. GDPman_DH.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500135. GDPman_DH. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiALGD_PSEPK
AccessioniPrimary (citable) accession number: Q88NC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi