Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q88MG7 (LPXB_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:PP_1604
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190178

Sequences

Sequence LengthMass (Da)Tools
Q88MG7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 258BA6E36138DA2B

FASTA37541,194
        10         20         30         40         50         60 
MAQLCVALVA GEASGDILGS GLMRALKARH PDVRFIGVGG PLMEAEGLQS YFPMERLAVM 

        70         80         90        100        110        120 
GLVEVLGRLR ELLKRRKLLI QTLIEEKPDV FIGIDAPDFT LNIELKLRQA GIKTVHYVSP 

       130        140        150        160        170        180 
SVWAWRQKRV LKIREGCDLM LTLLPFEARF YEEQGVPVRF VGHPLADTIP LEADRPAARA 

       190        200        210        220        230        240 
ALGLGEGPVV ALMPGSRGGE VGRLGALFLD AAERLSQQVP GVRFVLPCAN ATRRAQIEQM 

       250        260        270        280        290        300 
LEGRQLPLTL LDGQSHQALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRL 

       310        320        330        340        350        360 
VKSPYVSLPN LLAQRELVPE LLQDDATSEA LANTLAPLVR DGSQQTERFD EIHRTLRRDA 

       370 
SNQAAEAVLA LLKDR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015451 Genomic DNA. Translation: AAN67225.1.
RefSeqNP_743761.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88MG7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160488.PP_1604.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN67225; AAN67225; PP_1604.
GeneID1044937.
KEGGppu:PP_1604.
PATRIC19941434. VBIPsePut30601_1695.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBPRK00025.

Enzyme and pathway databases

BioCycPPUT160488:GIXO-1645-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_PSEPK
AccessionPrimary (citable) accession number: Q88MG7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways