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Q88MG7

- LPXB_PSEPK

UniProt

Q88MG7 - LPXB_PSEPK

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-1645-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:PP_1604
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Lipid-A-disaccharide synthasePRO_0000190178Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160488.PP_1604.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88MG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q88MG7-1 [UniParc]FASTAAdd to Basket

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    MAQLCVALVA GEASGDILGS GLMRALKARH PDVRFIGVGG PLMEAEGLQS    50
    YFPMERLAVM GLVEVLGRLR ELLKRRKLLI QTLIEEKPDV FIGIDAPDFT 100
    LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF 150
    YEEQGVPVRF VGHPLADTIP LEADRPAARA ALGLGEGPVV ALMPGSRGGE 200
    VGRLGALFLD AAERLSQQVP GVRFVLPCAN ATRRAQIEQM LEGRQLPLTL 250
    LDGQSHQALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRL 300
    VKSPYVSLPN LLAQRELVPE LLQDDATSEA LANTLAPLVR DGSQQTERFD 350
    EIHRTLRRDA SNQAAEAVLA LLKDR 375
    Length:375
    Mass (Da):41,194
    Last modified:June 1, 2003 - v1
    Checksum:i258BA6E36138DA2B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN67225.1.
    RefSeqiNP_743761.1. NC_002947.3.
    WP_010952682.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN67225; AAN67225; PP_1604.
    GeneIDi1044937.
    KEGGippu:PP_1604.
    PATRICi19941434. VBIPsePut30601_1695.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN67225.1 .
    RefSeqi NP_743761.1. NC_002947.3.
    WP_010952682.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88MG7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_1604.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN67225 ; AAN67225 ; PP_1604 .
    GeneIDi 1044937.
    KEGGi ppu:PP_1604.
    PATRICi 19941434. VBIPsePut30601_1695.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PPUT160488:GIXO-1645-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiLPXB_PSEPK
    AccessioniPrimary (citable) accession number: Q88MG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3