Reviewed, UniProtKB/Swiss-Prot Q88LV4 (GCH11_PSEPK)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1 1
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I 1
      Short name=GTP-CH-I 1

Gene names

Name:	folE1
Ordered Locus Names:	PP_1823

Organism

Pseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]

Taxonomic identifier

160488 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; dihydroneopterin triphosphate biosynthesis; 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	GTP cyclohydrolase 1 1 HAMAP MF_00223		PRO_0000119430

Sequences

	Sequence		Length	Mass (Da)
	Q88LV4-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E65550A866122653	FASTA	190	21,388
	10 20 30 40 50 60 MRFFPTGRSM SLEQNYTEIL SQIGEDVSRE GLLDTPKRAA KAMKYLCRGY EQTLEEVTNN 70 80 90 100 110 120 ALFSSDNSEM VLVRDIELYS MCEHHMLPFI GKAHVAYLPK GKVLGLSKVA RIVDMYARRL 130 140 150 160 170 180 QIQENLSRQI AEAVQQVTGA AGVAVVVEAK HMCMMMRGVE KQNSTMITSV MLGEFRDNAA 190 TRSEFLSLIK

References

[1]

"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440." Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O. , Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M. Environ. Microbiol. 4:799-808(2002) [PubMed: 12534463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015451 Genomic DNA. Translation: AAN67442.1.
RefSeq	NP_743978.1.
3D structure databases
HSSP	HSSP built from PDB template 1IS8 based on UniProtKB P22288.
ModBase	Search...
Genome annotation databases
GeneID	1043278.
GenomeReviews	Gene locus PP_1823 in contig AE015451_GR.
KEGG	ppu:PP_1823.
NMPDR	fig|160488.1.peg.1808.
TIGR	PP_1823.
Phylogenomic databases
HOGENOM	Q88LV4.
OMA	Q88LV4. ILPIIGR.
Enzyme and pathway databases
BioCyc	PPUT160488:PP_1823-MON.
Family and domain databases
HAMAP	MF_00223. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
ProDom	PD003330. GTP_cyclohydroI. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH11_PSEPK

Accession

Primary (citable) accession number: Q88LV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)