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Q88LC3

- NADK_PSEPK

UniProt

Q88LC3 - NADK_PSEPK

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Protein
NAD kinase
Gene
nadK, PP_2012
Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton acceptor By similarity
Binding sitei157 – 1571NAD By similarity
Binding sitei174 – 1741NAD By similarity
Binding sitei176 – 1761NAD By similarity
Binding sitei247 – 2471NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732NAD By similarity
Nucleotide bindingi146 – 1472NAD By similarity
Nucleotide bindingi187 – 1926NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-2074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:PP_2012
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296NAD kinaseUniRule annotation
PRO_0000120647Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_2012.

Structurei

3D structure databases

ProteinModelPortaliQ88LC3.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88LC3-1 [UniParc]FASTAAdd to Basket

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MEQFRNIGII GRLGSSQVLD TIRRLKKFLL DRHLHVILED TIAEVLPGHG    50
LQTSTRKLLG EVCDLVIVVG GDGSLLGAAR ALARHNIPVL GINRGNLGFL 100
TDIRPDELEQ KVAEVLDGHY LVENRFLLQA EVRRHHEAIG QGDALNDVVL 150
HPGKSTRMIE FEIYIDGQFV CSQKADGLIV ATPTGSTAYA LSAGGPIMHP 200
KLDAIVIVPM YPHTLSGRPI VVDGNSELKI VVSKDLQIYP QVSCDGQNHF 250
TCAPGDTITV SKKPQKLRLI HPLDHNYYEV CRTKLGWGSR LGSSDD 296
Length:296
Mass (Da):32,466
Last modified:August 22, 2003 - v2
Checksum:iDA5E6C69CA25640C
GO

Sequence cautioni

The sequence AAN67626.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN67626.1. Different initiation.
RefSeqiNP_744162.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN67626; AAN67626; PP_2012.
GeneIDi1042961.
KEGGippu:PP_2012.
PATRICi19942330. VBIPsePut30601_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN67626.1 . Different initiation.
RefSeqi NP_744162.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88LC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_2012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN67626 ; AAN67626 ; PP_2012 .
GeneIDi 1042961.
KEGGi ppu:PP_2012.
PATRICi 19942330. VBIPsePut30601_2122.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PPUT160488:GIXO-2074-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiNADK_PSEPK
AccessioniPrimary (citable) accession number: Q88LC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: July 9, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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