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Protein

3-dehydroquinate dehydratase 2

Gene

aroQ2

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.By similarity

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroF-I), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroF-II)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase 1 (aroQ1), 3-dehydroquinate dehydratase (aroQ-III), 3-dehydroquinate dehydratase 2 (aroQ2)
  4. Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE), Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. no protein annotated in this organism
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei19Transition state stabilizerBy similarity1
Active sitei24Proton acceptorBy similarity1
Binding sitei75SubstrateBy similarity1
Binding sitei81SubstrateBy similarity1
Binding sitei88SubstrateBy similarity1
Active sitei101Proton donorBy similarity1
Binding sitei112SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydratase 2 (EC:4.2.1.10)
Short name:
3-dehydroquinase 2
Alternative name(s):
Type II DHQase 2
Gene namesi
Name:aroQ2
Synonyms:aroQ-2
Ordered Locus Names:PP_2407
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001599211 – 1493-dehydroquinate dehydratase 2Add BLAST149

Interactioni

Subunit structurei

Homododecamer.By similarity

Protein-protein interaction databases

STRINGi160488.PP_2407.

Structurei

3D structure databases

ProteinModelPortaliQ88K84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 103Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.Curated

Phylogenomic databases

eggNOGiENOG4108Z38. Bacteria.
COG0757. LUCA.
HOGENOMiHOG000217278.
KOiK03786.
OMAiRCAGIVI.

Family and domain databases

CDDicd00466. DHQase_II. 1 hit.
Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ. 1 hit.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88K84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLILVLNG PNLNMLGTRE PAQYGHETLA DLAQGCADTA HAHGLEIEFR
60 70 80 90 100
QTNHEGELID WIHAARGRCA GIVINPGAWT HTSVAIRDAL VASELPVIEV
110 120 130 140
HLSNVHKREP FRHLSFVSSI AVGVICGLGS HGYRMALSHF AELLQERAA
Length:149
Mass (Da):16,211
Last modified:June 1, 2003 - v1
Checksum:iD10A4D670DA9D124
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN68019.1.
RefSeqiNP_744555.1. NC_002947.4.
WP_003250469.1. NC_002947.4.

Genome annotation databases

GeneIDi1045534.
KEGGippu:PP_2407.
PATRICi19943208. VBIPsePut30601_2550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN68019.1.
RefSeqiNP_744555.1. NC_002947.4.
WP_003250469.1. NC_002947.4.

3D structure databases

ProteinModelPortaliQ88K84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160488.PP_2407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1045534.
KEGGippu:PP_2407.
PATRICi19943208. VBIPsePut30601_2550.

Phylogenomic databases

eggNOGiENOG4108Z38. Bacteria.
COG0757. LUCA.
HOGENOMiHOG000217278.
KOiK03786.
OMAiRCAGIVI.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.

Family and domain databases

CDDicd00466. DHQase_II. 1 hit.
Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ. 1 hit.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAROQ2_PSEPK
AccessioniPrimary (citable) accession number: Q88K84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.