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Q88JY1 (GCH12_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1 2

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I 2
Short name=GTP-CH-I 2
Gene names
Name:folE2
Ordered Locus Names:PP_2512
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186GTP cyclohydrolase 1 2 HAMAP-Rule MF_00223
PRO_0000119431

Sequences

Sequence LengthMass (Da)Tools
Q88JY1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: D4F2562CC214F0F7

FASTA18620,886
        10         20         30         40         50         60 
MSHSLAEHYH EILVGIGENP QREGLLDTPR RAAKAMQYLC NGYAQDLHEV VNGALFESEN 

        70         80         90        100        110        120 
DEMIVVRDIE LYSLCEHHML PFIGKAHVAY LPTGRVLGLS KVARVVDMFA RRLQIQENLT 

       130        140        150        160        170        180 
RQIAYAVQEV TDAAGVGVVI EAKHMCMMMR GVEKQNSVMI SSVMLGAFRD APSTRHEFLN 


LIGRHN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015451 Genomic DNA. Translation: AAN68124.1.
RefSeqNP_744660.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88JY1.
SMRQ88JY1. Positions 11-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160488.PP_2512.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN68124; AAN68124; PP_2512.
GeneID1045754.
KEGGppu:PP_2512.
PATRIC19943446. VBIPsePut30601_2667.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAPRAYMER.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycPPUT160488:GIXO-2588-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH12_PSEPK
AccessionPrimary (citable) accession number: Q88JY1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways