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Protein

Arsenic resistance transcriptional regulator ArsR2

Gene

arsR2

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds arsenite and regulates the expression of arsenic efflux pumps. In vitro, also binds antimony and bismuth, but not arsenate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi30ArsenitePROSITE-ProRule annotationCurated1
Metal bindingi32ArsenitePROSITE-ProRule annotationCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi31 – 54H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processArsenical resistance, Transcription, Transcription regulation
LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenic resistance transcriptional regulator ArsR2Curated
Gene namesi
Name:arsR21 Publication
Synonyms:arsR-IIImported
Ordered Locus Names:PP_2718Imported
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Biotechnological usei

Could be used to construct robust and highly sensitive arsenic biosensors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004385131 – 115Arsenic resistance transcriptional regulator ArsR2Add BLAST115

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi160488.PP_2718.

Structurei

3D structure databases

ProteinModelPortaliQ88JD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90HTH arsR-typePROSITE-ProRule annotationAdd BLAST90

Phylogenomic databases

eggNOGiENOG41082YX. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
KOiK03892.
OMAiVCDLMEA.

Family and domain databases

CDDicd00090. HTH_ARSR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011991. ArsR-like_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88JD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITPPDVFKS LSDETRARAT LLIASLGELC VCELMCALND SQPKISRHLA
60 70 80 90 100
QLRSNGMLLD RRQGQWVYYR LNPELPSWVH EMLQVTLQAN SQWLADNALR
110
LKNMDGRPVR DSVCC
Length:115
Mass (Da):13,113
Last modified:June 1, 2003 - v1
Checksum:iB66F9603771FC6C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN68326.1.
RefSeqiNP_744862.1. NC_002947.4.
WP_010953634.1. NC_002947.4.

Genome annotation databases

EnsemblBacteriaiAAN68326; AAN68326; PP_2718.
GeneIDi1041740.
KEGGippu:PP_2718.
PATRICifig|160488.4.peg.2882.

Similar proteinsi

Entry informationi

Entry nameiARSR2_PSEPK
AccessioniPrimary (citable) accession number: Q88JD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: June 1, 2003
Last modified: January 31, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome