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Q88HM9

- GCH4_PSEPK

UniProt

Q88HM9 - GCH4_PSEPK

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPPUT160488:GIXO-3400-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PP_3324
OrganismiPseudomonas putida (strain KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314GTP cyclohydrolase FolE2PRO_0000147720Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_3324.

Structurei

3D structure databases

ProteinModelPortaliQ88HM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88HM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSALPDVSV TDLAPSLSPL QWVGMQGIDL PVRIQEPTYQ RELHARADVQ
60 70 80 90 100
VDLPAPHVKG IHMSRLYRLL DAWGQAAAVS PASLFALLQE MIDSHQDCES
110 120 130 140 150
RSARVRLDFD LLVRRPALVT EGLSGWKSYP VHVLATKVGG ALNLSIEVRI
160 170 180 190 200
GYSSTCPCSA ALSRQLIEDG FLRTFKDQPL LEVSAVAQWL RSNASLATPH
210 220 230 240 250
SQRSEARVRV TVPADAPDLG LLALIDHVEG ALRTPVQTAV KRADEQAFAA
260 270 280 290 300
LNGQNLMFVE DAARRIQASL HGYRDSQVHV RHLESLHPHD ASAWSAPQAA
310
APDQQESFAT GNER
Length:314
Mass (Da):34,316
Last modified:February 1, 2005 - v2
Checksum:i5C35C4315CA0AD4B
GO

Sequence cautioni

The sequence AAN68931.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN68931.1. Different initiation.
RefSeqiNP_745467.1. NC_002947.3.

Genome annotation databases

EnsemblBacteriaiAAN68931; AAN68931; PP_3324.
GeneIDi1046975.
KEGGippu:PP_3324.
PATRICi19945178. VBIPsePut30601_3534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015451 Genomic DNA. Translation: AAN68931.1 . Different initiation.
RefSeqi NP_745467.1. NC_002947.3.

3D structure databases

ProteinModelPortali Q88HM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160488.PP_3324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN68931 ; AAN68931 ; PP_3324 .
GeneIDi 1046975.
KEGGi ppu:PP_3324.
PATRICi 19945178. VBIPsePut30601_3534.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi QNLMYVE.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PPUT160488:GIXO-3400-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT2440.

Entry informationi

Entry nameiGCH4_PSEPK
AccessioniPrimary (citable) accession number: Q88HM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 1, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3