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Q88HM9 (GCH4_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:PP_3324
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence AAN68931.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147720

Sites

Site1561May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88HM9 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 5C35C4315CA0AD4B

FASTA31434,316
        10         20         30         40         50         60 
MSSALPDVSV TDLAPSLSPL QWVGMQGIDL PVRIQEPTYQ RELHARADVQ VDLPAPHVKG 

        70         80         90        100        110        120 
IHMSRLYRLL DAWGQAAAVS PASLFALLQE MIDSHQDCES RSARVRLDFD LLVRRPALVT 

       130        140        150        160        170        180 
EGLSGWKSYP VHVLATKVGG ALNLSIEVRI GYSSTCPCSA ALSRQLIEDG FLRTFKDQPL 

       190        200        210        220        230        240 
LEVSAVAQWL RSNASLATPH SQRSEARVRV TVPADAPDLG LLALIDHVEG ALRTPVQTAV 

       250        260        270        280        290        300 
KRADEQAFAA LNGQNLMFVE DAARRIQASL HGYRDSQVHV RHLESLHPHD ASAWSAPQAA 

       310 
APDQQESFAT GNER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015451 Genomic DNA. Translation: AAN68931.1. Different initiation.
RefSeqNP_745467.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88HM9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160488.PP_3324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN68931; AAN68931; PP_3324.
GeneID1046975.
KEGGppu:PP_3324.
PATRIC19945178. VBIPsePut30601_3534.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAFCEDAAR.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycPPUT160488:GIXO-3400-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_PSEPK
AccessionPrimary (citable) accession number: Q88HM9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways