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Q88HM9

- GCH4_PSEPK

UniProt

Q88HM9 - GCH4_PSEPK

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas putida (strain KT2440)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei156 – 1561May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPPUT160488:GIXO-3400-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:PP_3324
    OrganismiPseudomonas putida (strain KT2440)
    Taxonomic identifieri160488 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314GTP cyclohydrolase FolE2PRO_0000147720Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160488.PP_3324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88HM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiQNLMYVE.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q88HM9-1 [UniParc]FASTAAdd to Basket

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    MSSALPDVSV TDLAPSLSPL QWVGMQGIDL PVRIQEPTYQ RELHARADVQ    50
    VDLPAPHVKG IHMSRLYRLL DAWGQAAAVS PASLFALLQE MIDSHQDCES 100
    RSARVRLDFD LLVRRPALVT EGLSGWKSYP VHVLATKVGG ALNLSIEVRI 150
    GYSSTCPCSA ALSRQLIEDG FLRTFKDQPL LEVSAVAQWL RSNASLATPH 200
    SQRSEARVRV TVPADAPDLG LLALIDHVEG ALRTPVQTAV KRADEQAFAA 250
    LNGQNLMFVE DAARRIQASL HGYRDSQVHV RHLESLHPHD ASAWSAPQAA 300
    APDQQESFAT GNER 314
    Length:314
    Mass (Da):34,316
    Last modified:February 1, 2005 - v2
    Checksum:i5C35C4315CA0AD4B
    GO

    Sequence cautioni

    The sequence AAN68931.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN68931.1. Different initiation.
    RefSeqiNP_745467.1. NC_002947.3.

    Genome annotation databases

    EnsemblBacteriaiAAN68931; AAN68931; PP_3324.
    GeneIDi1046975.
    KEGGippu:PP_3324.
    PATRICi19945178. VBIPsePut30601_3534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015451 Genomic DNA. Translation: AAN68931.1 . Different initiation.
    RefSeqi NP_745467.1. NC_002947.3.

    3D structure databases

    ProteinModelPortali Q88HM9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160488.PP_3324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN68931 ; AAN68931 ; PP_3324 .
    GeneIDi 1046975.
    KEGGi ppu:PP_3324.
    PATRICi 19945178. VBIPsePut30601_3534.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi QNLMYVE.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PPUT160488:GIXO-3400-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT2440.

    Entry informationi

    Entry nameiGCH4_PSEPK
    AccessioniPrimary (citable) accession number: Q88HM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3