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Protein

5-dehydro-4-deoxyglucarate dehydratase

Gene

PP_3599

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 5-dehydro-4-deoxyglucarate dehydratase (PP_3599)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciPPUT160488:G1G01-3836-MONOMER
UniPathwayiUPA00564; UER00628

Names & Taxonomyi

Protein namesi
Recommended name:
5-dehydro-4-deoxyglucarate dehydratase (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:PP_3599
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001032341 – 3035-dehydro-4-deoxyglucarate dehydrataseAdd BLAST303

Proteomic databases

PRIDEiQ88GW8

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_3599

Structurei

3D structure databases

ProteinModelPortaliQ88GW8
SMRiQ88GW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ Bacteria
COG0329 LUCA
HOGENOMiHOG000173605
KOiK01707
OMAiRNRKKGY

Family and domain databases

CDDicd00951 KDGDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00694 KDGDH, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002220 DapA-like
IPR017655 Dehydro-deoxyglucarate_dehyd
PANTHERiPTHR12128 PTHR12128, 1 hit
PfamiView protein in Pfam
PF00701 DHDPS, 1 hit
PIRSFiPIRSF001365 DHDPS, 1 hit
SMARTiView protein in SMART
SM01130 DHDPS, 1 hit
TIGRFAMsiTIGR03249 KdgD, 1 hit

Sequencei

Sequence statusi: Complete.

Q88GW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPQELKSIL SHGLLSFPVT DFNAQGDFNP AGYIKRLEWL APYGASALFA
60 70 80 90 100
AGGTGEFFSL AASEYSQVIK TAVDTCATSV PILAGVGGST RQAIEYAQEA
110 120 130 140 150
ERLGAKGLLL LPHYLTEASQ DGVAAHVEAV CKSVNIGVVV YNRNVCRLNA
160 170 180 190 200
DLLEKLAERC PNLIGYKDGL GDIELMVSIR RRLGERFSYL GGLPTAEVYA
210 220 230 240 250
AAYKALGVPV YSSAVFNFVP KTAMDFYNAI ARDDHATVAK LIDDFFLPYL
260 270 280 290 300
DIRNRKAGYA VSIVKAGARI AGYDAGPVRT PLTDLTAEEY EMLAALMDKM

GPQ
Length:303
Mass (Da):32,661
Last modified:June 1, 2003 - v1
Checksum:iBFF75C61AFFD9227
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN69199.1
RefSeqiNP_745735.1, NC_002947.4
WP_010954445.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN69199; AAN69199; PP_3599
GeneIDi1046377
KEGGippu:PP_3599
PATRICifig|160488.4.peg.3827

Similar proteinsi

Entry informationi

Entry nameiKDGD_PSEPK
AccessioniPrimary (citable) accession number: Q88GW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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