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Protein

Catalase-peroxidase

Gene

katG

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87Transition state stabilizerUniRule annotation1
Active sitei91Proton acceptorUniRule annotation1
Metal bindingi285Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2381. PpuCP01_KT2440.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:PP_3668
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548681 – 751Catalase-peroxidaseAdd BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki90 ↔ 244Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-270)UniRule annotation
Cross-linki244 ↔ 270Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-90)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ88GQ0.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi160488.PP_3668.

Structurei

3D structure databases

ProteinModelPortaliQ88GQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q88GQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNESKCPFH QTAGGGTTNR DWWPDQLNLR ILHQHSSKSS PDPDFDYAKA
60 70 80 90 100
FKSLDFQALK KDLTALMTDS QDWWPADFGH YGPLFIRMAW HSAGTYRIGD
110 120 130 140 150
GRGGAGSGQQ RFAPLNSWPD NVSLDKARRL LWPIKQKYGN KISWADLIVL
160 170 180 190 200
TGNVALESMG FKTFGFSGGR ADVWEPDEDV YWGSEKVWLG GDTRYGKDQV
210 220 230 240 250
KAQPPGQGDL VAEPAKHGEE QNRDLSAERN LENPLAAVQM GLIYVNPEGP
260 270 280 290 300
EGNPDPVASG KDIRETFGRM AMNDEETVAL IAGGHAFGKT HGAGPADNVG
310 320 330 340 350
PEPEAAGLEM QGLGWHNTFG SGKGGDTITS GLEVTWTSTP TRWSNEYLNN
360 370 380 390 400
LFDFEWELTK SPAGAHQWRP KDGKGAGTVP DAHDPGKRHA PSMLTSDLAL
410 420 430 440 450
RFDPIYEPIA RHFKENPDQL ADAFARAWYK LIHRDMGPLA RYLGPEMPNE
460 470 480 490 500
ELLWQDPLPK ADPSTISEQD IATLKSRILA SGLSVGELVS TAWASASTFR
510 520 530 540 550
GSDKRGGANG ARLRLAPQKD WAANQGVDKV LAALEKIQGE FNSSGKKVSL
560 570 580 590 600
ADLIVLAGTA AVEKAAKDAG YSGSVGFRPG RVDASQEQTD VESFAVLEPL
610 620 630 640 650
ADGFRNFTKA RYSVKAEKLL LDKAQLLTLT APELTVLIGG LRVLGANHGG
660 670 680 690 700
SKLGVFTDKP GTLSNDFFRN LLDMSVEWKP TSADNETFEG RDRKTGQVKW
710 720 730 740 750
SGSRVDLVFG SHAQLRALSE VYASSDGGDK FVRDFVAAWQ KVMELDRFDL

K
Length:751
Mass (Da):82,062
Last modified:June 1, 2003 - v1
Checksum:i46A7DF2A2B49E957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN69268.1.
RefSeqiNP_745804.1. NC_002947.4.
WP_010954507.1. NC_002947.4.

Genome annotation databases

GeneIDi1045143.
KEGGippu:PP_3668.
PATRICi19945915. VBIPsePut30601_3903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA. Translation: AAN69268.1.
RefSeqiNP_745804.1. NC_002947.4.
WP_010954507.1. NC_002947.4.

3D structure databases

ProteinModelPortaliQ88GQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160488.PP_3668.

Protein family/group databases

PeroxiBasei2381. PpuCP01_KT2440.

Proteomic databases

PRIDEiQ88GQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1045143.
KEGGippu:PP_3668.
PATRICi19945915. VBIPsePut30601_3903.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PSEPK
AccessioniPrimary (citable) accession number: Q88GQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.