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Reviewed, UniProtKB/Swiss-Prot Q88EI4 (ASTD_PSEPK)

Last modified November 25, 2008. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD
Gene names
Name: astD
Ordered Locus Names: PP_4478
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords

   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487N-succinylglutamate 5-semialdehyde dehydrogenase
PRO_0000262416

Regions

Nucleotide binding221 – 2266NAD By similarity

Sites

Active site2441 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88EI4-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E681006D4C5FCE8A

FASTA48751,330
        10         20         30         40         50         60 
MTTHYIAGNW QAGQGETLQS LNPVTQAVIW QGQGADASQV DAAVQAARQA FPAWAQLSLE 

        70         80         90        100        110        120 
ARIDVLEKFA AQLKVHAEAM AQCIGEETGK PLWESATEVT SMINKVAISV QSYRERTGEK 

       130        140        150        160        170        180 
SGPLADATAV LRHKPHGVVA VFGPYNFPGH LPNGHIVPAL LAGNCVVFKP SELTPKVAEL 

       190        200        210        220        230        240 
TVNCWIAAGL PAGVLNLVQG ARETGVALAA NPGIDGLFFT GSSRTGNLLH QQFAGRPDKI 

       250        260        270        280        290        300 
LALEMGGNNP LVVDEVKDLD AAVYTIIQSA FISAGQRCTC ARRLLVPQGA WGDALIARLV 

       310        320        330        340        350        360 
EVCKTITVGA FDEQPAPFMG SVISLQAARA LLAAQVELAA KGGVKLLEMT QPQADAALLT 

       370        380        390        400        410        420 
PGIVDVTAVA DRPDEEFFGP LLQVIRYADF DAAIDEANNT QYGLAAGLLS DSRARYQYFW 

       430        440        450        460        470        480 
LRSRAGIVNW NKQLTGAASS APFGGVGASG NHRASAYYAA DYCAYPVASL ETASLALPAT 


LTPGVTL 

« Hide

Cross-references

Sequence databases

AE015451 Genomic DNA. Translation: AAN70053.1.
RefSeqNP_746589.1.

3D structure databases

HSSPHSSP built from PDB template 1O9J based on UniProtKB Q28399.
ModBaseSearch...

Genome annotation databases

GeneID1043982.
GenomeReviewsGene locus PP_4478 in contig AE015451_GR.
KEGGppu:PP_4478.
NMPDRfig|160488.1.peg.4419.
TIGRPP_4478.

Phylogenomic databases

HOGENOMQ88EI4.

Enzyme and pathway databases

BioCycPPUT160488:PP_4478-MON.

Family and domain databases

HAMAPMF_01174.
[Tree]
InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR015590. Aldehyde_DHase.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_PSEPK
AccessionPrimary (citable) accession number: Q88EI4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2003
Last modified: November 25, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents