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Q88EH6 (ACSA1_PSEPK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase 1
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase 1
Acyl-activating enzyme 1
Gene names
Name:acsA1
Synonyms:acsA
Ordered Locus Names:PP_4487
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length653 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 653653Acetyl-coenzyme A synthetase 1 HAMAP MF_01123
PRO_0000208376

Sites

Active site5171 By similarity

Amino acid modifications

Modified residue6091N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88EH6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: CE626C86C922E8F4

FASTA65371,797
        10         20         30         40         50         60 
MSAAPLYPVR PEVAATTLTD EATYKAMYQQ SVINPDGFWR EQAQRIDWIK PFTKVKQTSF 

        70         80         90        100        110        120 
DDHHVDIKWF ADGTLNVSSN CLDRHLEERG DQLAIIWEGD DPSEHRNITY RELHEQVCKF 

       130        140        150        160        170        180 
ANALRGQDVH RGDVVTIYMP MIPEAVVAML ACARIGAIHS VVFGGFSPEA LAGRIIDCKS 

       190        200        210        220        230        240 
KVVITADEGV RGGRRTPLKA NVDLALTNPE TSSVQKIIVC KRTGGDIAWH QHRDIWYEDL 

       250        260        270        280        290        300 
MKVASSHCAP KEMGAEEALF ILYTSGSTGK PKGVLHTTGG YLVYAALTHE RVFDYRPGEV 

       310        320        330        340        350        360 
YWCTADVGWV TGHSYIVYGP LANGATTLLF EGVPNYPDIT RVSKIVDKHK VNILYTAPTA 

       370        380        390        400        410        420 
IRAMMAEGQA AVEGADGSSL RLLGSVGEPI NPEAWNWYYK TVGKERCPIV DTWWQTETGG 

       430        440        450        460        470        480 
ILISPLPGAT GLKPGSATRP FFGVVPALVD NLGNLIDGAA EGNLVILDSW PGQSRSLYGD 

       490        500        510        520        530        540 
HDRFVDTYFK TFRGMYFTGD GARRDEDGYY WITGRVDDVL NVSGHRMGTA EIESAMVAHS 

       550        560        570        580        590        600 
KVAEAAVVGV PHDIKGQGIY VYVTLNAGIE ASEQLRLELK NWVRKEIGPI ASPDVIQWAP 

       610        620        630        640        650 
GLPKTRSGKI MRRILRKIAT GEYDALGDIS TLADPGVVQH LIDTHKAMNL ASA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015451 Genomic DNA. Translation: AAN70062.1.
RefSeqNP_746598.1. NC_002947.3.

3D structure databases

ProteinModelPortalQ88EH6.
SMRQ88EH6. Positions 7-647.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ88EH6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1042436.
GenomeReviewsGene locus PP_4487 in contig AE015451_GR.
KEGGppu:PP_4487.
NMPDRfig|160488.1.peg.4428.
PATRIC19947676. VBIPsePut30601_4775.
TIGRPP_4487.

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMATRGTEES.
PhylomeDBQ88EH6.
ProtClustDBPRK00174.

Enzyme and pathway databases

BioCycPPUT160488:PP_4487-MONOMER.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA1_PSEPK
AccessionPrimary (citable) accession number: Q88EH6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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