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Protein

Peptide deformylase 2

Gene

def2

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101IronUniRule annotation1
Metal bindingi143IronUniRule annotation1
Active sitei144UniRule annotation1
Metal bindingi147IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciPPUT160488:G1G01-4867-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 2UniRule annotation
Alternative name(s):
Polypeptide deformylase 2UniRule annotation
Gene namesi
Name:def2UniRule annotation
Ordered Locus Names:PP_4559
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828211 – 178Peptide deformylase 2Add BLAST178

Proteomic databases

PRIDEiQ88EA7

Interactioni

Protein-protein interaction databases

STRINGi160488.PP_4559

Structurei

3D structure databases

ProteinModelPortaliQ88EA7
SMRiQ88EA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108RBJ Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
KOiK01462
OMAiDGFHARV

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q88EA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRDILKMGD ERLLRIAPPV PEHMLGSAEL QQLIDDMFET MRHVGGVGLA
60 70 80 90 100
APQVGIDLQL VIFGFERSER YPDAEAVPQT ILLNPVITPT SSEVEDGWEG
110 120 130 140 150
CLSVPGLRGV VPRFKHICYQ GIDPQGSPIN RFADGFHARV VQHECDHLIG
160 170
RLYPSRIQDF AKFGYTEVLF PGLEVSED
Length:178
Mass (Da):19,852
Last modified:June 1, 2003 - v1
Checksum:i044749D0EE6738C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN70132.1
RefSeqiNP_746668.1, NC_002947.4
WP_010955231.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN70132; AAN70132; PP_4559
GeneIDi1046247
KEGGippu:PP_4559
PATRICifig|160488.4.peg.4862

Similar proteinsi

Entry informationi

Entry nameiDEF2_PSEPK
AccessioniPrimary (citable) accession number: Q88EA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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