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Reviewed, UniProtKB/Swiss-Prot Q88E47 (HGD_PSEPK)

Last modified November 4, 2008. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase
Gene names
Name: hmgA
Ordered Locus Names: PP_4621
OrganismPseudomonas putida (strain KT2440) [Complete proteome] [HAMAP]
Taxonomic identifier160488 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Homogentisate + O(2) = 4-maleylacetoacetate.

Cofactor

Iron By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Homogentisate 1,2-dioxygenase
PRO_0000220250

Sites

Metal binding3311Iron By similarity
Metal binding3371Iron By similarity
Metal binding3671Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88E47-1 [UniParc].

Last modified June 6, 2003. Version 1.
Checksum: 6D5F4C7F91BE4512

FASTA43348,011
        10         20         30         40         50         60 
MNRDTSPDLH YLSGFGNEFA SEALPGALPV GQNSPQKAPY GLYAELLSGT AFTMARSELR 

        70         80         90        100        110        120 
RTWLYRIRPS ALHPRFERLA RQPLGGPLGG INPNRLRWSP QPIPAEPTDF IEGWLPMAAN 

       130        140        150        160        170        180 
AGAEKPAGVS IYIYRANRSM ERVFFNADGE LLLVPEQGRL RIATELGVME VEPLEIAVIP 

       190        200        210        220        230        240 
RGMKFRVELL DGQARGYIAE NHGAPLRLPD LGPIGSNGLA NPRDFLTPVA HYEEAEGPVQ 

       250        260        270        280        290        300 
LVQKFLGEHW ACELQHSPLD VVAWHGSNVP YKYDLRRFNT IGTVSFDHPD PSIFTVLTSP 

       310        320        330        340        350        360 
TSVHGMANMD FVIFPPRWMV AENTFRPPWF HRNLMNEFMG LINGAYDAKA EGFLPGGASL 

       370        380        390        400        410        420 
HGVMSAHGPD AETCEKAIAA DLAPHKIDNT MAFMFETSQV LRPSLQALEC PQLQADYDSC 

       430 
WATLPSTFNP NRR 

« Hide

Cross-references

Sequence databases

AE015451 Genomic DNA. Translation: AAN70194.1.
RefSeqNP_746730.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1041590.
GenomeReviewsGene locus PP_4621 in contig AE015451_GR.
KEGGppu:PP_4621.
NMPDRfig|160488.1.peg.4560.
TIGRPP_4621.

Phylogenomic databases

HOGENOMQ88E47.

Enzyme and pathway databases

BioCycPPUT160488:PP_4621-MON.

Family and domain databases

HAMAPMF_00334.
[Tree]
InterProIPR005708. Homogentis_dOase.
[Graphical view]
PANTHERPTHR11056. Homogentis_dOase. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_PSEPK
AccessionPrimary (citable) accession number: Q88E47
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: November 4, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents